Medicina clinica
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Numerous epidemiological studies link bone loss with vascular calcification and cardiovascular disease. Osteoporosis and atherosclerosis share risk factors and are likely to share pathogenic mechanisms as well. On the other hand, drugs used in the treatment of osteoporosis could influence cardiovascular risk, just as those used in cardiovascular disease could affect bone mineral density and the development of fractures.
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Tumor necrosis factor-alpha inhibitor (anti-TNF-α) agents are essential in treating inflammatory bowel diseases (IBD). Their use, however, may cause dermatoses. This study aims to characterize the dermatoses in IBD patients on anti-TNF-α therapy. ⋯ The prevalence of dermatoses, considering together, was higher in the anti-TNF-α group. Infections, alopecia, seborrheic dermatitis, administration reactions, and psoriasiform eruptions were the most frequent dermatoses in patients taking anti-TNF-α.