Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Nov 2019
Multicenter Study Observational StudyImpact of natural menopause on multiple sclerosis: a multicentre study.
To study the effect of natural menopause on multiple sclerosis clinical course. ⋯ Natural menopause seems to be a turning point to a more progressive phase of MS. Relapse rate is also reduced after menopause, but this effect could be driven most by ageing and shifting to progressive phase in patients with long-lasting disease. Cigarette smoking could speed up disability progression after menopause.
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J. Neurol. Neurosurg. Psychiatr. · Oct 2019
Multicenter StudyImage-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study.
Deep brain stimulation (DBS) can be an effective therapy for tics and comorbidities in select cases of severe, treatment-refractory Tourette syndrome (TS). Clinical responses remain variable across patients, which may be attributed to differences in the location of the neuroanatomical regions being stimulated. We evaluated active contact locations and regions of stimulation across a large cohort of patients with TS in an effort to guide future targeting. ⋯ The results collectively indicate that DBS may improve tics and OCB, the effects may develop over several months, and stimulation locations relative to structural anatomy alone may not predict response. This study was the first to visualise and evaluate the regions of stimulation across a large cohort of patients with TS to generate new hypotheses about potential targets for improving tics and comorbidities.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2019
Multicenter StudyMulticentre, population-based, case-control study of particulates, combustion products and amyotrophic lateral sclerosis risk.
To investigate whether exposure to particulates and combustion products may explain the association between certain occupations and amyotrophic lateral sclerosis (ALS) risk in a large, multicentre, population-based, case-control study, based on full job histories, using job-exposure matrices, with detailed information on possible confounders. ⋯ In a large, multicentre study, using harmonised methodology to objectively quantify occupational exposure to particulates and combustion products, we found an association between ALS risk and exposure to silica, independent of the other occupational exposures studied.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2019
Multicenter StudyCurrent epidemiology of cerebrospinal fluid shunt surgery in the UK and Ireland (2004-2013).
To determine current epidemiology and clinical characteristics of cerebrospinal fluid (CSF) shunt surgery, including revisions. ⋯ Our report informs patients, carers, clinicians, providers and commissioners of healthcare, researchers and industry of the current epidemiology of shunting for CSF disorders, including the potential risks of complications and frequency of revision.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2019
Randomized Controlled Trial Multicenter Study Pragmatic Clinical TrialMulticentre, randomised controlled trial of PDSAFE, a physiotherapist-delivered fall prevention programme for people with Parkinson's.
To estimate the effect of a physiotherapist-delivered fall prevention programme for people with Parkinson's (PwP). ⋯ PDSAFE did not reduce falling in this pragmatic trial of PwP. Other functional tasks improved and reduced fall rates were apparent among those with moderate disease.