Journal of neurology, neurosurgery, and psychiatry
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Over the last 30 years neurovirology has emerged as a major discipline which has much relevance to both human disease and many aspects of neuroscience. This overview of the field aims to define briefly most of the major neurovirological techniques, both "classical" and more recent, and to indicate how these have been used to gain knowledge about the pathogenesis, clinical investigation, and treatment of viral infections of the central nervous system.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2003
Meta AnalysisHead injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication.
To determine, using a systematic review of case-control studies, whether head injury is a significant risk factor for Alzheimer's disease. We sought to replicate the findings of the meta-analysis of Mortimer et al (1991). ⋯ This study provides support for an association between a history of previous head injury and the risk of developing Alzheimer's disease.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2003
ReviewSurgery for Parkinson's disease: lack of reliable clinical trial evidence.
There has been a striking resurgence of interest in surgery for Parkinson's disease (PD) with new targets identified and new procedures developed. This systematic review identified over 500 studies of surgery for PD published since 1990, including over 10 000 patients. ⋯ Studies of surgery for PD have generally been of poor quality with too few patients, too short follow up, inappropriate choice of outcome measures, and lack of control groups. Much larger, randomised, controlled trials are needed to assess the longer term effects of surgery on patient rated quality of life and cost effectiveness.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2003
ReviewSurgery for Parkinson's disease: lack of reliable clinical trial evidence.
There has been a striking resurgence of interest in surgery for Parkinson's disease (PD) with new targets identified and new procedures developed. This systematic review identified over 500 studies of surgery for PD published since 1990, including over 10 000 patients. ⋯ Studies of surgery for PD have generally been of poor quality with too few patients, too short follow up, inappropriate choice of outcome measures, and lack of control groups. Much larger, randomised, controlled trials are needed to assess the longer term effects of surgery on patient rated quality of life and cost effectiveness.