Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Nov 2024
Cardiovascular risk and obesity impact loss of grey matter volume earlier in males than females.
It remains imperative to discover the time course that cardiovascular risk factors influence neurodegeneration in males and females and decipher whether the apolipoprotein (APOE) genotype mediates this relationship. Here we perform a large-scale evaluation of the influence of cardiovascular risk and obesity on brain volume in males and females in different age groups. ⋯ The strongest influence of cardiovascular risk and obesity on reduced brain volume was between 55-64 years of age in males, whereas women were most susceptible to the detrimental effects of cardiovascular risk a decade later between 65-74 years of age. Here we elucidate the timing that targeting cardiovascular risk factors and obesity should be implemented in males and females to prevent neurodegeneration and Alzheimer's disease development.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2024
Risk of fall with device-based advanced treatments in Parkinson's disease: a systematic review and network meta-analysis.
Deep brain stimulation (DBS) and infusion therapies are effective treatments for the motor complications of Parkinson's disease (PD), but less established is their role in fall prevention. This systematic review and network meta-analysis (NMA) aimed to evaluate the risk of falls associated with advanced therapies in PD. ⋯ CRD42023420637.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2024
Complete nanopore repeat sequencing of SCA27B (GAA-FGF14 ataxia) in Japanese.
Although pure GAA expansion is considered pathogenic in SCA27B, non-GAA repeat motif is mostly mixed into longer repeat sequences. This study aimed to unravel the complete sequencing of FGF14 repeat expansion to elucidate its repeat motifs and pathogenicity. ⋯ FGF14 repeat expansion has unique features of pathogenicity and allelic origin, as revealed by a single ethnic study.