Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jul 2021
Meta AnalysisRisk factors for cognitive impairment in amyotrophic lateral sclerosis: a systematic review and meta-analysis.
Cognitive impairment is a common, far-reaching but imperceptible manifestation in patients with amyotrophic lateral sclerosis (ALS). We aimed to identify the risk factors for cognitive impairment in ALS. ⋯ CRD42020201085.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2021
Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes.
To test the hypothesis that in syndromes associated with frontotemporal lobar degeneration, behavioural impairment predicts loss of functional independence and motor clinical features predict mortality, irrespective of diagnostic group. ⋯ Our results can assist individualised prognostication and planning of disease-modifying trials, and they support a transdiagnostic approach to symptomatic treatment trials in patients with clinical syndromes associated with frontotemporal lobar degeneration.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2021
Brain structural alterations in MOG antibody diseases: a comparative study with AQP4 seropositive NMOSD and MS.
Brain structural alterations and their clinical significance of myelin oligodendrocyte glycoprotein antibody disease (MOGAD) have not been determined. ⋯ MOGAD demonstrated cortical and subcortical atrophy without severe WM rarefaction. The subcortical GM volume correlated with clinical disability and a combination of MRI and clinical measures could separate MOGAD from AQP4+ NMOSD and MS.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2021
Multicenter Study Observational StudyGuillain-Barré syndrome and COVID-19: an observational multicentre study from two Italian hotspot regions.
Single cases and small series of Guillain-Barré syndrome (GBS) have been reported during the SARS-CoV-2 outbreak worldwide. We evaluated incidence and clinical features of GBS in a cohort of patients from two regions of northern Italy with the highest number of patients with COVID-19. ⋯ This study shows an increased incidence of GBS during the COVID-19 outbreak in northern Italy, supporting a pathogenic link. COVID-19-associated GBS is predominantly demyelinating and seems to be more severe than non-COVID-19 GBS, although it is likely that in some patients the systemic impairment due to COVID-19 might have contributed to the severity of the whole clinical picture.