Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Dec 2005
Randomized Controlled Trial Multicenter StudyCannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up.
To test the effectiveness and long term safety of cannabinoids in multiple sclerosis (MS), in a follow up to the main Cannabinoids in Multiple Sclerosis (CAMS) study. ⋯ These data provide limited evidence for a longer term treatment effect of cannabinoids. A long term placebo controlled study is now needed to establish whether cannabinoids may have a role beyond symptom amelioration in MS.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2005
Randomized Controlled TrialModafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial.
Excessive daytime somnolence (EDS) commonly complicates Parkinson's disease (PD). The aetiology of EDS is probably multifactorial but is probably exacerbated by dopaminergic medications. Modafinil is a wake-promoting agent approved for use in narcolepsy, but it is often used to treat a variety of somnolent conditions. ⋯ Modafinil failed to significantly improve EDS in PD compared with placebo. The drug did not alter motor symptoms in PD and was well tolerated.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2005
Randomized Controlled Trial Multicenter Study Clinical TrialDonepezil for dementia in Parkinson's disease: a randomised, double blind, placebo controlled, crossover study.
To study the safety and efficacy of a cholinesterase inhibitor, donepezil hydrochloride, for the treatment of dementia in Parkinson's disease (PD). ⋯ Donepezil was well tolerated and did not worsen PD. There may be a modest benefit on aspects of cognitive function. The possible clinical benefit measured by CGI was reflected in only one of the cognitive scales used in this study.
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J. Neurol. Neurosurg. Psychiatr. · Oct 2004
Randomized Controlled Trial Clinical TrialEfficacy of deep brain stimulation of the subthalamic nucleus in Parkinson's disease 4 years after surgery: double blind and open label evaluation.
To evaluate the long term (4 years) efficacy of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in advanced Parkinson's disease. ⋯ DBS of the STN provides a significant and persistent anti-parkinsonian effect in advanced Parkinson's disease 4 years after surgery.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Randomized Controlled Trial Comparative Study Clinical TrialRandomised control trial of tongue acupuncture versus sham acupuncture in improving functional outcome in cerebral palsy.
Traditional Chinese medicine (TCM) has been used historically in the treatment of cerebral palsy (CP). We investigated the efficacy of acupuncture in improving the motor function of children with CP. ⋯ An improvement in motor function of CP subjects is seen following a short course of acupuncture.