Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Apr 2012
Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia.
Relatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia. ⋯ Prospective studies are now needed to see whether identification of CASPR2 antibodies has relevance for the diagnosis and treatment of idiopathic cerebellar ataxia.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2012
Letter Case ReportsMyasthenia gravis can cause camptocormia.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2012
Biography Historical ArticleNerve fibre degeneration in the brain in amyotrophic lateral sclerosis.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2012
Sera from neuromyelitis optica patients disrupt the blood-brain barrier.
In neuromyelitis optica (NMO), the destruction of the blood-brain barrier (BBB) has been considered to be the first step of the disease process. It is unclear whether sera from patients with NMO can open the BBB, and which component of patient sera is most important for this disruption. ⋯ Sera from NMO patients reduce expression of tight junction proteins and disrupt the BBB. Autoantibodies against BMECs other than anti-AQP4 antibodies may disrupt the BBB through upregulation of VEGF in BMECs.