Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jan 2007
Case ReportsTemporal sensitivity in a hemianopic visual field can be improved by long-term training using flicker stimulation.
Blindness of a visual half-field (hemianopia) is a common symptom after postchiasmatic cerebral lesions. Although hemianopia severely limits activities of daily life, current clinical practice comprises no training of visual functions in the blind hemifield. ⋯ Results show that sensitivity to flicker could be fully restored in the stimulated region, that improvement in sensitivity spreads to the surrounding neuronal networks, and that, during training, accompanying changes occurred in the neuromagnetic fields.
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J. Neurol. Neurosurg. Psychiatr. · Jan 2007
Influence of subjective visual vertical misperception on balance recovery after stroke.
Subjective visual vertical (SVV) perception can be perturbed after stroke, but its effect on balance recovery is not yet known. ⋯ Initial misperception of verticality was related to a poor score for balance after stroke. This relationship seems to be independent of motricity and neglect. Rehabilitation programmes should take into account verticality misperceptions, which could be an important factors influencing balance recovery after stroke.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2006
Review Meta AnalysisEffects of apolipoprotein E genotype on outcome after ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage.
Rodent models of acute ischaemic stroke and head injury suggest that apolipoprotein E (APOE) genotype influences neuronal repair, regeneration and survival after brain injury. Possession of an APOE epsilon4 allele is associated with poor outcome after head injury in clinical studies. APOE might therefore influence outcome after acute stroke in humans. ⋯ APOE may differentially affect outcome after the three main pathological types of stroke. Further, large studies are needed to confirm or refute these findings, and to assess the possibility of an interaction between the effects of APOE and age.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2006
Clinical TrialEffect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies.
Levodopa (L-dopa) is the gold standard treatment for Parkinson's disease, but a lack of clear efficacy combined with a perceived liability to neuropsychiatric side effects has limited L-dopa use in patients with parkinsonism and dementia. Therefore, the effect of L-dopa on the cognitive profile of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is unclear. ⋯ The use of L-dopa in patients with parkinsonism with dementia does not adversely affect cognitive function.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2006
Acute physiological derangement is associated with early radiographic cerebral infarction after subarachnoid haemorrhage.
Cerebral infarction after aneurysmal subarachnoid haemorrhage (SAH) is presumed to be due to cerebral vasospasm, defined as arterial lumen narrowing from days 3 to 14. ⋯ Many cerebral infarctions after SAH are unlikely to be caused by vasospasm because they occur too soon after SAH or because angiography shows no vasospasm in a referable artery, or both. Physiological derangement and cerebral oedema may be worthwhile targets for intervention to decrease the occurrence and clinical impact of cerebral infarction after SAH.