Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Apr 2004
Religiosity is associated with hippocampal but not amygdala volumes in patients with refractory epilepsy.
To assess the relationship between the behavioural triad of hyper-religiosity, hypergraphia and hyposexuality in epilepsy, and volumes of the mesial temporal structures. ⋯ These findings suggest that right hippocampal volumes are negatively correlated with religiosity in patients with refractory epilepsy.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2004
Case ReportsProgressive auditory neuropathy in patients with Leber's hereditary optic neuropathy.
To investigate auditory neural involvement in patients with Leber's hereditary optic neuropathy (LHON). ⋯ The findings are consistent with auditory neuropathy-a lesion of the cochlear nerve presenting with abnormal auditory brain stem responses and with normal inner hair cells and the cochlear nucleus (lower brain stem). The association of auditory neuropathy, or any other auditory dysfunction, with LHON has not been recognised previously. Further studies are necessary to establish whether this is a consistent finding.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2004
Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease.
Recent transcranial magnetic stimulation (TMS) studies demonstrate that motor cortex excitability is increased in Alzheimer's disease (AD) and that intracortical inhibitory phenomena are impaired. The aim of the present study was to determine whether hyperexcitability is due to the impairment of intracortical inhibitory circuits or to an independent abnormality of excitatory circuits. ⋯ The change in threshold did not seem to correlate with dysfunction of inhibitory intracortical cholinergic and GABAergic circuits, nor with the central cholinergic activity. We propose that the hyperexcitability of the motor cortex is caused by an abnormality of intracortical excitatory circuits.