Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · May 1989
Prevention of hydrocephalus shunt catheter colonisation in vitro by impregnation with antimicrobials.
A process is described by which hydrocephalus shunt catheters can be impregnated with antimicrobials. The processed catheters showed antimicrobial activity at their surfaces for long periods and could be sterilised by autoclaving. ⋯ Resistant organisms did not develop. The process is likely to be useful in prevention of hydrocephalus shunt infection.
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J. Neurol. Neurosurg. Psychiatr. · Apr 1989
Clinical TrialVigabatrin in the treatment of epilepsy: a long-term follow-up study.
Twenty-five adult epileptic patients who had shown a satisfactory clinical response to add-on vigabatrin under placebo-controlled conditions continued on long-term treatment for up to 47 months (median 22 months). The initially favourable therapeutic response was generally maintained throughout the observation period with an overall good clinical tolerance. No evidence of neurotoxicity was detected by multimodal evoked potentials monitoring.
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J. Neurol. Neurosurg. Psychiatr. · Aug 1988
Accuracy of the clinical diagnosis of vascular dementia: a prospective clinical and post-mortem neuropathological study.
Brains from a prospective study of demented patients were investigated post mortem. Of the 27 patients with clinical diagnosis of vascular dementia, 23 showed multiple cerebral infarcts but senile plaques and neurofibrillary tangles were absent or in insignificant numbers. This gives an accuracy of 85%, a figure higher than previously documented.
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J. Neurol. Neurosurg. Psychiatr. · May 1988
Case ReportsHarlequin syndrome: the sudden onset of unilateral flushing and sweating.
Facial flushing and sweating were investigated in five patients who complained of the sudden onset of unilateral facial flushing in hot weather or when exercising vigorously. One patient probably suffered a brainstem infarct at the time that the unilateral flush was first noticed, and was left with a subtle Horner's syndrome on the side opposite to the flush. The other four had no other neurological symptoms and no ocular signs of Horner's syndrome. ⋯ The complaint of unilateral flushing and sweating was abolished in one patient by ipsilateral stellate ganglionectomy. The unilateral facial flushing and sweating induced by heat in all five patients was thus a normal or excessive response by an intact sympathetic pathway, the other side failing to respond because of a sympathetic deficit. The onset in the four cases of peripheral origin followed strenuous exertion, which suggested that an anterior radicular artery may have become occluded at the third thoracic segment during torsion of the thoracic spine.