Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Apr 2020
Review Meta AnalysisPoor prognosis associated with TERT gene alterations in meningioma is independent of the WHO classification: an individual patient data meta-analysis.
TERT gene alterations (TERT-alt) have been linked to increased risk of recurrence in meningiomas, whereas the association to mortality largely remain incompletely investigated. As incongruence between clinical course and WHO grade exists, reliable biomarkers have been sought. ⋯ TERT-alt is an important biomarker for significantly higher risk of recurrence and death in meningiomas. TERT-alt should be managed and surveilled aggressively. We propose that TERT-alt analysis should be implemented as a routine diagnostic test in meningioma and integrated into the WHO classification.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2020
Meta AnalysisSleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis.
To conduct an updated systematic review and meta-analysis of association between sleep and all-cause cognitive disorders. ⋯ Sleep management might serve as a promising target for dementia prevention.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2019
Meta AnalysisLatitude continues to be significantly associated with the prevalence of multiple sclerosis: an updated meta-analysis.
Previous studies have demonstrated a strong latitudinal gradient in multiple sclerosis (MS) prevalence. Herein, we present a meta-analysis of the latitudinal gradient of MS prevalence including studies published since our 2011 review, seeking to assess the latitudinal gradient and whether it has changed since our previous analysis. ⋯ This new meta-analysis confirms that MS prevalence is still strongly positively associated with increasing latitude and that the gradient is increasing, suggesting that potentially modifiable environmental factors, such as sun exposure, are still strongly associated with MS risk.