Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Dec 2019
Multicenter StudyPredicting symptomatic intracranial haemorrhage after mechanical thrombectomy: the TAG score.
There is limited data on predictors of symptomatic intracranial haemorrhage (sICH) in patients who underwent mechanical thrombectomy. In this study, we aim to determine those predictors with external validation. ⋯ High TAG scores are associated with sICH in patients receiving mechanical thrombectomy. Larger studies are needed to validate this scoring system and test strategies to reduce sICH risk and make thrombectomy safer in patients with elevated TAG scores.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2019
Multicenter StudyPrognostic patterns and predictors in epilepsy: a multicentre study (PRO-LONG).
To describe the long-term prognosis of epilepsy and prognostic patterns in a large cohort of newly diagnosed patients and identify prognostic factors. ⋯ Few seizures at diagnosis, generalised epilepsy and no psychiatric comorbidity predict early or late seizure freedom in epilepsy. Achieving remission at any time after the diagnosis does not exclude further relapses.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2019
Multicenter Study Observational StudyImpact of natural menopause on multiple sclerosis: a multicentre study.
To study the effect of natural menopause on multiple sclerosis clinical course. ⋯ Natural menopause seems to be a turning point to a more progressive phase of MS. Relapse rate is also reduced after menopause, but this effect could be driven most by ageing and shifting to progressive phase in patients with long-lasting disease. Cigarette smoking could speed up disability progression after menopause.
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J. Neurol. Neurosurg. Psychiatr. · Oct 2019
Multicenter StudyImage-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study.
Deep brain stimulation (DBS) can be an effective therapy for tics and comorbidities in select cases of severe, treatment-refractory Tourette syndrome (TS). Clinical responses remain variable across patients, which may be attributed to differences in the location of the neuroanatomical regions being stimulated. We evaluated active contact locations and regions of stimulation across a large cohort of patients with TS in an effort to guide future targeting. ⋯ The results collectively indicate that DBS may improve tics and OCB, the effects may develop over several months, and stimulation locations relative to structural anatomy alone may not predict response. This study was the first to visualise and evaluate the regions of stimulation across a large cohort of patients with TS to generate new hypotheses about potential targets for improving tics and comorbidities.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2019
Multicenter StudyMulticentre, population-based, case-control study of particulates, combustion products and amyotrophic lateral sclerosis risk.
To investigate whether exposure to particulates and combustion products may explain the association between certain occupations and amyotrophic lateral sclerosis (ALS) risk in a large, multicentre, population-based, case-control study, based on full job histories, using job-exposure matrices, with detailed information on possible confounders. ⋯ In a large, multicentre study, using harmonised methodology to objectively quantify occupational exposure to particulates and combustion products, we found an association between ALS risk and exposure to silica, independent of the other occupational exposures studied.