Medicine
-
Previous research has indicated a possible link between mobile phone usage and the incidence of glaucoma. This study employs a 2-sample Mendelian randomization (MR) analysis to examine the causal relationship between mobile phone use and glaucoma risk. We used single nucleotide polymorphisms (SNPs) from publicly accessible genome-wide association study (GWAS) datasets as instrumental variables (IVs). ⋯ The results demonstrate a causal effect of mobile phone usage on an increased risk of glaucoma (ORIVW = 1.358, 95% CI: 1.052-1.752, P = .019; ORMR-Egger = 1.882, 95% CI: 0.53-6.682, P = .337; ORWeighted median = 1.387, 95% CI: 1.012-1.900, P = .042; ORMR-PRESSO = 1.358, 95% CI: 1.052-1.752, P = .026). Sensitivity analyses confirmed the robustness and reliability of these findings. The study identifies mobile phone usage as a potentially modifiable risk factor for glaucoma, providing new avenues for exploring the specific mechanisms underlying these ocular disorders.
-
Spermatic cord myxomas are rare benign tumors, typically characterized by the production of mucopolysaccharides. These tumors are infrequently found in the urinary system, making this case noteworthy. ⋯ Although rare, spermatic cord myxomas should be considered in the differential diagnosis of scrotal masses. Surgical excision is both diagnostic and therapeutic, providing a favorable prognosis with minimal risk of recurrence.
-
Bronchitis is a common respiratory disease characterized by acute inflammation, edema, and necrosis of the small airways, leading to a significant pathological burden. Immune cells play a crucial role in combating bronchitis. This study aims to explore the causal relationship between immune cells and bronchitis using the Mendelian randomization approach. ⋯ Moreover, the study validated the robustness of these findings through leave-one-out analysis and the MR-Egger method, and quantitatively illustrated the impact of immune cells on the risk of bronchitis through forest plots. This study reveals the dual role of immune cells in bronchitis. The identified types of immune cells may increase the risk of bronchitis by promoting inflammatory responses and cell-mediated immune reactions, while other cell types may offer protection by promoting immune balance and effective defense.
-
The high incidence, disability, mortality, and recurrence rates of cerebral infarction impose a heavy burden on both the Chinese and global populations. It is essential for the early diagnosis, prevention, and protection against brain cell injury. To identify differentially expressed microRNAs (miRNAs) in plasma exosomes of patients with cerebral ischemic stroke, determine relevant biomarkers, and explore their potential signaling pathways. ⋯ Gene Ontology, Kyoto Encyclopedia of Genes, and genomes enrichment analyses indicated that the differentially expressed miRNAs and their target genes were mainly concentrated in the PI3K-AKt, mitogen-activated protein kinase, calcium, Ras, Rap1, and cAMP signaling pathways. The expression of plasma exosomal hsa-miR-1303, hsa-miR-125b-1-3p, and hsa-miR-1289 was significantly different in stroke patients than in the control group. These miRNAs may be involved in various signaling pathways related to cerebral infarction, providing a reference for further experimental research.
-
Bioinformatics analysis helps to understand the underlying mechanisms and adjust diagnostic and treatment strategies for immunoglobulin A nephropathy (IgAN) by screening gene expression datasets. We explored the biological function of IgAN, and established and validated a diagnostic model for IgAN using weighted gene co-expression network analysis. Using the GSE93798 and GSE37460 datasets, we performed differential expression analysis, Gene Oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, constructed a protein-protein network, and identified hub genes. ⋯ The calibration plot indicated that the nomogram-predicted probability of nonadherence was highly correlated with actual diagnosed nonadherence, and the decision curve analysis indicated that patients had a relatively good net benefit. The model and gene expression were also validated using an external dataset. Our study provides directions for exploring the potential molecular mechanisms of IgAN as well as diagnostic and therapeutic strategies.