JAMA : the journal of the American Medical Association
-
Randomized Controlled Trial Clinical Trial
Reducing children's television viewing to prevent obesity: a randomized controlled trial.
Some observational studies have found an association between television viewing and child and adolescent adiposity. ⋯ Reducing television, videotape, and video game use may be a promising, population-based approach to prevent childhood obesity.
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group.
Risedronate, a potent bisphosphonate, has been shown to be effective in the treatment of Paget disease of bone and other metabolic bone diseases but, to our knowledge, it has not been evaluated in the treatment of established postmenopausal osteoporosis. ⋯ These data suggest that risedronate therapy is effective and well tolerated in the treatment of women with established postmenopausal osteoporosis.
-
Randomized Controlled Trial Clinical Trial
Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment.
Influenza virus neuraminidase is thought to be essential for virus replication in humans; however, to date, available neuraminidase inhibitors are limited to zanamivir, which is topically administered. ⋯ In these trials, prophylaxis and early treatment with oral oseltamivir were both associated with significant antiviral and clinical effects in experimental human influenza.