Nutrition
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Randomized Controlled Trial
Time-of-day effects of consumption of fish oil-enriched sausages on serum lipid parameters and fatty acid composition in normolipidemic adults: A randomized, double-blind, placebo-controlled, and parallel-group pilot study.
The body clock controls diurnal rhythms of nutrient digestion, absorption, and metabolism. Fish oil (FO) contains abundant ω-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), that are thought to lower triglyceride (TG) levels. This randomized, placebo-controlled, double-blind, parallel-group trial aimed to confirm the effects of the time of FO intake on TG in healthy Japanese adults. ⋯ These findings suggested that the timing of FO intake affects both serum FA concentrations and TG metabolism in normolipidemic humans. The mechanisms of these effects of FO on lipid metabolism require further investigation.
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Randomized Controlled Trial
Oral chronic sulforaphane effects on heavy resistance exercise: Implications on inflammatory and muscle damage parameters in young practitioners.
Sulforaphane is a phytochemical that is commonly found in broccoli and broccoli sprouts. However, whether chronic sulforaphane ingestion suppresses heavy resistance exercise-induced muscle damage parameters in humans remains unknown. Therefore, this study investigated the effects of oral chronic sulforaphane ingestion on heavy resistance exercise-induced muscle damage parameters. ⋯ Together, these findings suggest that the oral chronic intake of sulforaphane suppressed the heavy resistance exercise-induced increase in muscle damage parameter and expression of inflammatory cytokines. The chronic use of sulforaphane may be a novel therapeutic candidate for the prevention of muscle damage in athletes training daily with high-intensity exercise.
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Randomized Controlled Trial
Dose effect of bovine lactoferrin fortification on diarrhea and respiratory tract infections in weaned infants with anemia: A randomized, controlled trial.
The aim of this study was to explore the dose effect of bovine lactoferrin (bLF) fortification on the morbidity of diarrhea and respiratory tract infections in weaned infants with anemia. ⋯ The bLF-fortified formula was effective in reducing the morbidity of diarrhea and RTIs in infants with anemia, with the 76 mg/100 g bLF-fortified formula exhibiting a stronger effect. The bLF fortification could be a new strategy for the prevention of diarrhea and RTIs in infants with anemia.
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Randomized Controlled Trial
Effect of arabinogalactan on the gut microbiome: A randomized, double-blind, placebo-controlled, crossover trial in healthy adults.
Promising evidence suggests beneficial health effects of arabinogalactan, but little is known about the effect of this non-digestible carbohydrate on the gut microbiota, a crucial mediator of human health. The objective of this study was to investigate the effect of an arabinogalactan product (ResistAid) on the fecal microbiome and short-chain fatty acids and gastrointestinal tolerance in healthy adults in a randomized, double-blind, crossover trial. ⋯ These results demonstrate that the gut microbiome composition and predicted functions can be modulated by ResistAid consumption, perhaps suggesting a mechanistic explanation on its reported benefits in metabolic parameters and the immune system.