Nutrition
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We investigated the effect of dietary glutamine (Gln) on specific antibody production and antioxidant enzyme activities in burned mice vaccinated with detoxified Pseudomonas exotoxin A linked with the outer membrane proteins I and F (PEIF). We also evaluated the survival rate of vaccinated and non-vaccinated burned mice infected with Pseudomonas aeruginosa. ⋯ These results suggested that vaccinated mice receiving a Gln-enriched diet may have enhanced humoral immunity and attenuated oxidative stress induced by burn injury. Also, Gln supplementation improved the survival of burned mice complicated with P. aeruginosa infection.
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Randomized Controlled Trial Clinical Trial
Effect of hypocaloric meals with different macronutrient compositions on energy metabolism and lung function in obese women.
We investigated the effect of hypocaloric mixed diets with different proportions of carbohydrate, protein, and fat on resting metabolic rate and the thermic effect of food in obese women. ⋯ Obese women with normal lung function tests and consuming mixed hypocaloric diets showed no alteration in resting metabolic rate and a reduced or absent thermic effect of food independently of the macronutrient composition.
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We investigated associations between human leukocyte antigen class II genes, environmental exposures, and Helicobacter pylori infection. ⋯ These findings suggested that H. pylori infection is not influenced by a genetic compound and confirmed the relevance of environmental exposure.