Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Jul 2001
Meta AnalysisThe influence of a dominating centre on a quantitative systematic review of granisetron for preventing postoperative nausea and vomiting.
We performed a meta-analysis on granisetron in the prevention of postoperative nausea and vomiting (PONV) and further investigated whether total results and the dose-response characteristics may be significantly affected by a single centre. ⋯ Overall results and dose-response characteristics of meta-analyses may be significantly altered by one dominating centre. Further, if data of a dominating centre do not appear to be valid for other centres, it may seem advisable to either exclude them from the analysis or to perform sub-group analyses so that results without the data from the dominating centre are available.