Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 2015
Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis.
Osteopontin (OPN) is a multifunctional glycoprotein with pro-inflammatory properties. In severe sepsis, levels of plasma OPN are significantly higher in non-survivors than in survivors. We hypothesized that OPN results in greater inflammation and worse outcome through modulation of endogenous glucocorticoid production in sepsis. ⋯ OPN is associated with greater inflammatory response and increased mortality, despite the higher corticosterone levels in plasma. Corticosterone production is not impaired in the absence of OPN.
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Acta Anaesthesiol Scand · Feb 2015
Editorial Biography Historical ArticleOn the quest for stress-free surgical operations.