Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2015
Review Meta AnalysisPeripherally applied opioids for postoperative pain: evidence of an analgesic effect? A systematic review and meta-analysis.
Opioids applied peripherally at the site of surgery may produce postoperative analgesia with few side effects. We performed this systematic review to evaluate the analgesic effect of peripherally applied opioids for acute postoperative pain. ⋯ Evidence of a clinically relevant analgesic effect of peripherally applied opioids for acute postoperative pain is lacking. The analgesic effect of peripherally applied opioids may depend on the presence of preoperative inflammation.