Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 2019
Review Meta AnalysisDopamine in critically ill patients with cardiac dysfunction: A systematic review with meta-analysis and trial sequential analysis.
Dopamine has been used in patients with cardiac dysfunction for more than five decades. Yet, no systematic review has assessed the effects of dopamine in critically ill patients with cardiac dysfunction. ⋯ Evidence for dopamine in critically ill patients with cardiac dysfunction is sparse, of low quality, and inconclusive. The use of dopamine for cardiac dysfunction can neither be recommended nor refuted.
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Acta Anaesthesiol Scand · Apr 2019
Review Meta AnalysisLactate versus acetate buffered crystalloid solutions: Protocol for a scoping review.
Intravenous (IV) fluid therapy has become a ubiquitous intervention in everyday clinical practice. Several types of fluid are available including isotonic crystalloid fluids. Among crystalloid fluids, buffered solutions (derivatives of the original Hartmann's and Ringer's solutions) are increasingly recommended as first-line resuscitation fluids. However, the choice between different buffered solutions appears to be difficult with limited data to support the use of lactate vs. acetate buffered solutions. Accordingly, we aim at systematically describing the body of evidence on the use of the different types of buffered crystalloid solutions in hospitalised patients. ⋯ This outlined scoping review will provide a summary of the current body of evidence on the use, effects and side-effects of buffered crystalloid solutions. This will provide an important update of the current evidence on the use, of "buffered" crystalloid solutions including evidence of potential benefits and harms.
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Acta Anaesthesiol Scand · Apr 2019
Review Meta AnalysisDexmedetomidine for the management of delirium in critically ill patients-A protocol for a systematic review.
Delirium is a common complication in critically ill patients and carries an increased risk of mortality and morbidity. Dexmedetomidine can potentially treat delirium by diminishing predisposing factors. The evidence regarding the use of dexmedetomidine in the management of delirium is conflicting. This protocol aims to identify the beneficial and harmful effects of dexmedetomidine in the management of delirium. ⋯ This systematic review can potentially aid clinicians in decision making and benefit the many critically ill patients developing delirium.
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Acta Anaesthesiol Scand · Apr 2019
Review Meta AnalysisDexmedetomidine for the prevention of delirium in critically ill patients - A protocol for a systematic review.
Delirium is a common complication in critically ill patients and carries an increased risk of mortality and morbidity. Dexmedetomidine can potentially prevent delirium by diminishing predisposing factors. The evidence regarding the use of dexmedetomidine in preventing delirium is conflicting. This protocol aims to identify the beneficial and harmful effects of dexmedetomidine in the prevention of delirium. ⋯ This systematic review can potentially aid clinicians in decision-making and benefit the many critically ill patients at risk of delirium.