International journal of clinical practice
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Int. J. Clin. Pract. · Sep 2021
Review Meta AnalysisComparison of efficacy of various drugs used for medical expulsive therapy for distal ureter stones: a systematic review and network meta-analysis.
Medical expulsive therapy has been found to be effective for distal ureteric stones; however, which drug is most efficacious in terms of stone expulsion rate (SER) and stone expulsion time (SET) is not known. With this review we aimed to compare the efficacy of various drug treatments for distal ureter stones used as medical expulsive therapy in terms of SER and SET. ⋯ For lower ureter stone, tadalafil plus silodosin is the best combination and silodosin best individual drug considering the SET and SER. Nifedipine as monotherapy is no more effective than control group.
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Int. J. Clin. Pract. · Sep 2021
Meta AnalysisMedication adherence to injectable glucagon-like peptide-1 (GLP-1) receptor agonists dosed once-weekly versus once-daily in patients with type 2 diabetes: a meta-analysis.
Suboptimal medication adherence has been associated with increased resource utilisation and mortality among patients with type 2 diabetes (T2D). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are becoming increasingly important in the treatment of T2D. However, medications in this class differ considerably in their dosing frequency, which may impact adherence. We sought to perform a meta-analysis to compare adherence to injectable GLP-1RAs dosed once weekly vs once daily in patients with T2D. ⋯ Once weekly dosing of injectable GLP-1RAs was associated with better adherence vs once daily dosing among patients with T2D. These findings coupled with the known detrimental consequences of non-adherence suggest that dosing frequency is an important factor to consider when selecting a GLP-1RA.
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Int. J. Clin. Pract. · Sep 2021
ReviewA pre-systematic review on use of masks as protection material for SARS-COV-2 during COVID-19 pandemic.
Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China on 31 December 2019. ⋯ Universal wearing of facemasks in the community is likely to be recommended during the COVID-19pandemic. Since SARS-COV-2 is highly contagious, a set of measures should be considered. Facemask sanitisation is possible, but standardised procedures are lacking. New PE is emerging and requires detailed regulatory approval. It is advisable to monitor public opinion.
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Int. J. Clin. Pract. · Sep 2021
Meta AnalysisThe effect of soy products on circulating adiponectin and leptin concentration in adults: A systematic review and meta-analysis of randomized controlled trials.
Human clinical trials that have investigated the effect of soy product consumption on adipokines have reported inconsistent results. Our objective was to elucidate the role of soy product consumption on adiponectin and leptin in adults through a systematic review and meta-analysis of available randomised placebo-controlled trials (RCTs). ⋯ The present systematic review and meta-analysis suggest that soy product consumption had no significant effect on leptin and adiponectin levels in adults. However, future larger and well-designed trials are still needed to further explore this research area and to address the heterogeneous study design used in the existing literature.
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Int. J. Clin. Pract. · Sep 2021
ReviewDelayed and cancelled orthopaedic surgery; are there solutions to reduce the complex set of problems?
Unexpected cancellations of, and delays to, orthopaedic surgery have adverse effects, with a negative impact on hospital performance and undesirable patient outcomes. As cancellations and delays are common, finding measures to prevent them is a matter of urgency. ⋯ This systematic literature review has revealed important evidence to help reduce the risk of cancelled and delayed orthopaedic procedures associated with a variety of care action exposures. They include a fast-track pathway, pre-operative guidelines and telephone contact with patients prior to surgery, as well as careful consideration of additional pre-operative tests.