International journal of clinical practice
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Int. J. Clin. Pract. · Sep 2021
Meta AnalysisMedication adherence to injectable glucagon-like peptide-1 (GLP-1) receptor agonists dosed once-weekly versus once-daily in patients with type 2 diabetes: a meta-analysis.
Suboptimal medication adherence has been associated with increased resource utilisation and mortality among patients with type 2 diabetes (T2D). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are becoming increasingly important in the treatment of T2D. However, medications in this class differ considerably in their dosing frequency, which may impact adherence. We sought to perform a meta-analysis to compare adherence to injectable GLP-1RAs dosed once weekly vs once daily in patients with T2D. ⋯ Once weekly dosing of injectable GLP-1RAs was associated with better adherence vs once daily dosing among patients with T2D. These findings coupled with the known detrimental consequences of non-adherence suggest that dosing frequency is an important factor to consider when selecting a GLP-1RA.
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Int. J. Clin. Pract. · Sep 2021
Meta AnalysisExtracorporeal membrane oxygenation versus mechanical ventilation alone in adults with severe acute respiratory distress syndrome: a systematic review and meta-analysis.
COVID-19 can lead to acute respiratory distress syndrome (ARDS). Extracorporeal membrane oxygenation (ECMO) is considered to be a salvage strategy for severe ARDS. However, the effect of ECMO therapy on severe ARDS remains inconclusive. We aimed to evaluate the effects of ECMO for adults with severe ARDS. ⋯ This study showed that the ECMO group exhibited a significantly lower mortality rate compared with the MV alone group at 90, 30 and 60 days for severe ARDS patients.
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Int. J. Clin. Pract. · Sep 2021
ReviewCommunity Pharmacists' knowledge, attitudes and practices towards oral healthcare and its management: a systematic review.
Community pharmacists play a significant part in providing oral healthcare advice as there are significant connections between oral healthcare and body system healthcare. ⋯ Community pharmacists were lacking knowledge on oral health mainly because of paucity in providing appropriate training courses. This has led to poor practices towards oral healthcare as they were unable to provide suitable products recommendations to the patients. This has led the community pharmacists into lack of attitudes in providing oral health information. However, most of the community pharmacists were conscious of their role in the oral healthcare system and were willing to improve their knowledge of oral healthcare.
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Int. J. Clin. Pract. · Sep 2021
ReviewSARS-CoV-2/HBV Co-infected Patients: A case series and review of the literature.
We aimed to determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/hepatitis B virus (HBV) coinfection affects liver function and the outcome of the disease. ⋯ SARS-CoV-2/HBV coinfection did not change the severity and outcome of COVID-19. However, the patients with SARS-CoV-2/HBV coinfection should be closely monitored for liver complications.
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Int. J. Clin. Pract. · Sep 2021
Randomized Controlled TrialThe efficacy of Alpha-Lipoic Acid in improving oxidative, inflammatory and mood status in women with episodic migraine in a randomized, double-blind, placebo-controlled clinical trial.
Migraine is a common neurovascular disorder, which is associated with severe to moderate disabling headaches. Oxidative stress and inflammation might play a role in migraine pathogenesis and the mood disorders. Considering the antioxidant and anti-inflammatory properties of alpha-lipoic acid (ALA), this study was designed to investigate its effect on oxidative, inflammatory, and mood conditions in women with episodic migraine. ⋯ The results of this study suggest that ALA supplementation for 3 months has beneficial effects on improving the oxidative, inflammatory, and mood conditions of patients suffering from episodic migraine.