International journal of clinical practice
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Int. J. Clin. Pract. · Sep 2021
Randomized Controlled TrialA prospective, randomized clinical study comparing triple therapy regimen to hydrocortisone monotherapy in reducing mortality in septic shock patients.
This prospective, comparative and randomised clinical study evaluated the effectiveness of triple therapy regimen (hydrocortisone, thiamine and vitamin C) versus hydrocortisone alone in reducing the mortality rate and preventing progressive organ dysfunction in septic shock patients. ⋯ Vitamin C, thiamine, and hydrocortisone regimen for septic shock management showed non-significant efficacy in decreasing 28-day mortality when compared to hydrocortisone monotherapy. On the other hand, it showed significant efficacy in decreasing the shock time and duration on vasopressors.
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Int. J. Clin. Pract. · Sep 2021
Meta AnalysisDiagnostic value of NPTX2 (neuronal pentraxin II) methylation in patients with pancreatic cancer: meta-analysis.
Pancreatic cancer (PC) is a devasting disease of which mortality almost parallels its incidence. PC tissue may express aberrantly methylated neuronal pentraxin II (NPTX2), but it is unclear what the consequences of this are. ⋯ NPTX2 methylation could serve as a promising molecular biomarker for pancreatic cancer diagnosis, for its high diagnostic value in differentiating pancreatic cancer from benign pancreatic disease with the lab method. The variable sensitivity of methylated NPTX2 was multifactorial, and it must be promoted before applied as screening test in clinical practice. Furthermore, experiments on methylated NPTX2 were needed to expanded for lower the heterogeneity.
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Int. J. Clin. Pract. · Sep 2021
Assessment of the Need for Pharmacogenomics Education among Pharmacists in the West Bank of Palestine.
Pharmacogenomics testing aims to optimise therapy and reduce the inter-individual variation in drug response. One of the major barriers against the implementation of pharmacogenomics testing is the low level of knowledge on the topic. ⋯ It is seen from the results of this study that there is a high need to learn about pharmacogenomics testing, which can help the pharmacists make pharmacotherapy decisions. Additionally, current pharmacists have low self-confidence in making decisions depending on the results of pharmacogenomics testing. It is recommended to increase the exposure of pharmacogenomics knowledge by including the subject in courses and workshops in pharmacy school curricula in the West Bank of Palestine.
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Int. J. Clin. Pract. · Sep 2021
Randomized Controlled TrialEffectiveness of kinesiotaping in pregnant women with sacroiliac joint pain: A randomised controlled study.
Sacroiliac joint (SIJ) dysfunction is an especially common cause of pain during pregnancy. Treatment options during pregnancy are very limited in order to reduce pain and increase the quality of life. We aimed to determine the efficacy of kinesiotaping (KT) in the treatment of SIJ pain in pregnant women. ⋯ KT treatment improved the pain levels, functioning and quality of life among pregnant women with SIJ pain.
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Int. J. Clin. Pract. · Sep 2021
Randomized Controlled TrialComparison of the fracture strength of endodontically treated teeth restored with polyether ether ketone, zirconia and glass-fiber post-core systems.
This study aimed to compare the fracture resistance and fracture mode of maxillary central incisors restored with four different sizes and three different post-core systems. ⋯ PEEK post-cores showed sufficient fracture strength for the anterior region, similar to the other two post-core materials. PEEK post-cores showed more decementation and repairable fractures at lower forces, while restoration failure was mostly catastrophic for glass-fibre and zirconia posts.