British medical bulletin
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British medical bulletin · Sep 2023
Meta AnalysisDrug repurposing for COVID-19: current evidence from randomized controlled adaptive platform trials and living systematic reviews.
The coronavirus disease 2019 (COVID-19) pandemic resulted in a race to develop effective treatments largely through drug repurposing via adaptive platform trials on a global scale. Drug repurposing trials have focused on potential antiviral therapies aimed at preventing viral replication, anti-inflammatory agents, antithrombotic agents and immune modulators through a number of adaptive platform trials. Living systematic reviews have also enabled evidence synthesis and network meta-analysis as clinical trial data emerge globally. ⋯ The timing of therapeutic interventions based on postulated mechanisms of action and the selection of clinically meaningful primary end points remain important considerations in the design and implementation of COVID-19 therapeutic trials.
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British medical bulletin · Sep 2023
Meta AnalysisEfficacy of hydrodilatation in frozen shoulder: a systematic review and meta-analysis.
It is unclear whether hydrodilatation is beneficial in the management of frozen shoulder compared with other common conservative management modalities. This systematic review evaluates the efficacy of hydrodilatation for the management of frozen shoulder. ⋯ Although current evidence suggests that hydrodilatation provides a transient improvement in disability in patients with frozen shoulder, its clinical relevance remains unclear. Further research is necessary to establish its role in the management of the condition.
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British medical bulletin · Apr 2023
Meta AnalysisDoes femoroacetabular impingement syndrome affect range of motion? A systematic review with meta-analysis.
It is unclear whether femoroacetabular impingement syndrome (FAIS) affect hip range of motion (ROM). ⋯ Further studies are needed to resolve the uncertainty of evidence about ROM restrictions in asymptomatic FAIm compared to healthy controls.
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British medical bulletin · Apr 2023
Meta AnalysisKnee osteoarthritis, joint laxity and PROMs following conservative management versus surgical reconstruction for ACL rupture: a meta-analysis.
Patients whose rupture of the anterior cruciate ligament (ACL) can be managed conservatively or undergo reconstruction surgery. ⋯ ACL reconstruction provides significant improvement in joint laxity compared to conservative management, but is associated with a significantly greater rate of knee osteoarthritis, despite similar results at PROM assessment.
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British medical bulletin · Sep 2022
Meta AnalysisLigament Advanced Reinforcement System (LARS) synthetic graft for PCL reconstruction: systematic review and meta-analysis.
Several strategies are available for posterior cruciate ligament (PCL) reconstruction. ⋯ LARS for primary isolated PCL reconstruction seems to be effective and safe, with results comparable to the 4SHT autograft.