Mayo Clinic proceedings
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Mayo Clinic proceedings · May 2015
Review Meta AnalysisEffect of Protocolized Sedation on Clinical Outcomes in Mechanically Ventilated Intensive Care Unit Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
To assess the effects of protocolized sedation (algorithm or daily interruption) compared with usual care without protocolized sedation on clinical outcomes in mechanically ventilated adult intensive care unit (ICU) patients via a systematic review and meta-analysis of randomized controlled trials (RCTs). ⋯ In mechanically ventilated adults in closed, nonspecialty ICUs, protocolized sedation seems to decrease overall mortality (15%), ICU and hospital lengths of stay (1.73 and 3.55 days, respectively), and tracheostomy (31%) compared with usual care without protocolized sedation.
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Mayo Clinic proceedings · Jan 2015
Review Meta AnalysisThe safety of intravenous iron preparations: systematic review and meta-analysis.
To amass all available evidence regarding the safety of intravenous (IV) iron preparations to provide a true balance of efficacy and safety. ⋯ Intravenous iron therapy is not associated with an increased risk of SAEs or infections. Infusion reactions are more pronounced with IV iron.
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Mayo Clinic proceedings · Dec 2014
Review Meta Analysis Comparative StudyComparative efficacy of biologic therapy in biologic-naïve patients with Crohn disease: a systematic review and network meta-analysis.
To study the comparative efficacy of biologic therapy in the management of biologic-naïve patients with Crohn disease (CD). ⋯ On the basis of network meta-analysis, IFX may be most efficacious agent for inducing remission in CD in biologic-naïve patients. In the absence of head-to-head treatment comparison, the confidence in these estimates is low. Future comparative efficacy studies are warranted.
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Mayo Clinic proceedings · Oct 2014
Review Meta AnalysisThe prognostic importance of weight loss in coronary artery disease: a systematic review and meta-analysis.
To assess the prognostic impact of weight loss on clinical outcomes in patients with coronary artery disease (CAD). ⋯ Whereas observational weight loss is associated with increased adverse cardiovascular events, intentional weight loss is associated with lower clinical events. These results suggest that the underlying mechanism of weight loss (ie, intentional or unintentional) affects its impact on subsequent risk in persons with known CAD.
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Mayo Clinic proceedings · Aug 2014
Meta AnalysisRelationship of body mass index with total mortality, cardiovascular mortality, and myocardial infarction after coronary revascularization: evidence from a meta-analysis.
To investigate the relationship of body mass index (BMI) with total mortality, cardiovascular (CV) mortality, and myocardial infarction (MI) after coronary revascularization procedures (coronary artery bypass grafting [CABG] and percutaneous coronary intervention [PCI]). ⋯ After coronary artery disease revascularization procedures (PCI and CABG), the risk of total mortality, CV mortality, and MI was highest among underweight patients as defined by low BMI and CV mortality was lowest among overweight patients.