Mayo Clinic proceedings
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Mayo Clinic proceedings · Oct 2014
Review Meta AnalysisThe prognostic importance of weight loss in coronary artery disease: a systematic review and meta-analysis.
To assess the prognostic impact of weight loss on clinical outcomes in patients with coronary artery disease (CAD). ⋯ Whereas observational weight loss is associated with increased adverse cardiovascular events, intentional weight loss is associated with lower clinical events. These results suggest that the underlying mechanism of weight loss (ie, intentional or unintentional) affects its impact on subsequent risk in persons with known CAD.
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Mayo Clinic proceedings · Aug 2014
Meta AnalysisRelationship of body mass index with total mortality, cardiovascular mortality, and myocardial infarction after coronary revascularization: evidence from a meta-analysis.
To investigate the relationship of body mass index (BMI) with total mortality, cardiovascular (CV) mortality, and myocardial infarction (MI) after coronary revascularization procedures (coronary artery bypass grafting [CABG] and percutaneous coronary intervention [PCI]). ⋯ After coronary artery disease revascularization procedures (PCI and CABG), the risk of total mortality, CV mortality, and MI was highest among underweight patients as defined by low BMI and CV mortality was lowest among overweight patients.
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Mayo Clinic proceedings · Mar 2014
Meta AnalysisA pooled analysis of waist circumference and mortality in 650,000 adults.
To assess the independent effect of waist circumference on mortality across the entire body mass index (BMI) range and to estimate the loss in life expectancy related to a higher waist circumference. ⋯ In white adults, higher waist circumference was positively associated with higher mortality at all levels of BMI from 20 to 50 kg/m(2). Waist circumference should be assessed in combination with BMI, even for those in the normal BMI range, as part of risk assessment for obesity-related premature mortality.
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Mayo Clinic proceedings · Nov 2013
Review Meta AnalysisStatins and cognition: a systematic review and meta-analysis of short- and long-term cognitive effects.
To evaluate the effect of statins on short-term cognitive function and the long-term incidence of dementia. ⋯ In patients without baseline cognitive dysfunction, short-term data are most compatible with no adverse effect of statins on cognition, and long-term data may support a beneficial role for statins in the prevention of dementia.
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Mayo Clinic proceedings · Oct 2013
Review Meta AnalysisEndovascular therapy for acute ischemic stroke: a systematic review and meta-analysis.
To consolidate the evidence from randomized trials for the use of endovascular therapy (ET) in patients with acute ischemic stroke. ⋯ Overall, ET is not superior to IV thrombolysis for acute ischemic strokes (level B recommendation). However, ET showed promise and improved outcomes in patients with severe strokes, but the evidence is limited due to sample size. There is a need for further trials evaluating the role of ET in this high-risk group.