Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
-
Hunan Yi Ke Da Xue Xue Bao · Apr 2001
[Clinical use of interlocking intramedullary nail treating in complex and nonunion fracture of femur and tibia].
Fifty-one complex and nonunion fractures of femur and tibia in forty eight patients were treated with interlocking intramedullary nail. All patients were followed-up for 6 to 29 months to evaluate the curative effect. Forty-nine fractures in forty-six patients were healed(95.8%). ⋯ In femur, the efficacy of 28 cases was excellent or good (93.3%), and 2 cases mediate (6.7%); in tibia, 18 cases were all assessed as excellent or good. The complications were observed in 8 patients (16.67%), including distal screw misinserting, extremity shortening, screw loosening, distal shaft fracture and fracture nonunion. The results suggest that interlocking intramedullary nail can be used in many kinds of femur and tibia fracture with satisfactory result, especially in the complex fracture and nonunion after fixation failure.
-
Hunan Yi Ke Da Xue Xue Bao · Feb 2001
[Protective effects of sevoflurane pretreatment on myocardial ischemia-reperfusion injury in rabbits].
To observe the myocardial protective effects of sevoflurane pretreatment on ischemia-reperfusion injury, forty eight rabbits were divided into six groups randomly: control group, ischemia-preconditioning group, sevoflurane preconditioning group, ischemia preconditioning plus glyburide group, sevoflurane preconditioning plus glyburide group, glyburide group, each group subjected to three hours of left anterion descending coronary artery occlusion followed by three hours of reperfusion. Infarct size and area at risk were defined by staining. ⋯ Glyburide alone did not increase infarct size [IS:AR = (63.2 +/- 12.5)%, not significant]. It suggests that sevoflurane pretreatment protects the rabbit heart subjected to three hours of coronary occlusion from infarction.
-
Hunan Yi Ke Da Xue Xue Bao · Dec 2000
Randomized Controlled Trial Clinical Trial[The efficacy of the native flumazenil for acute poisoning with benzodiazepines].
To evaluate the efficacy of the native flumazenil for acute self-poisoning with benzodiazepines. ⋯ Flumazenil might improve benzodiazepines-induced unconsciousness markedly and may be the most effective antagonist of benzodiazepines.
-
Hunan Yi Ke Da Xue Xue Bao · Oct 2000
Randomized Controlled Trial Clinical Trial[Protective effects of low dose nitric oxide inhalation on lung ischemia/reperfusion injury during cardiopulmonary bypass surgery].
Out aim is to study the effects of inhaling nitric oxide(NO) on the pulmonary ischemia/reperfusion injury during cardiopulmonary bypass surgery. ⋯ 1. If aortic clamp time is over 1 h, lung ischemia/reperfusion injury may occur during cardio-pulmonary bypass surgery. 2. Inhaling 20 ppm NO in the early phase of reperfusion has protective effects on the lung ischemia/reperfusion injury during cardio-pulmonary bypass surgery. 3. The mechanisms of the protective effects may be related with the increase of cGMP and the decrease of ICAM-1, XOD, MDA.
-
Hunan Yi Ke Da Xue Xue Bao · Aug 2000
Randomized Controlled Trial Clinical Trial[Ischemic preconditioning decrease the release of cardiac troponin T during heart valve replacement].
Using cardiac troponin T(cTnT), a highly sensitive and specific marker of myocardial injury, we evaluated the effects of ischemic precondition on ischemic reperfusion myocardial injury. Thirty two patients were randomly divided into control group(n = 16) and ischemic preconditioning group(n = 16). ⋯ The results showed that the peak value of cTnT was lower, and more quickly recovered in the preconditioning group than that in the control. It is suggested that ischemic preconditioning exert an evidently protective effect on ischemic reperfusion myocardial injury.