Revista de saúde pública
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Revista de saúde pública · Oct 2008
Randomized Controlled TrialEffectiveness of daily and weekly iron supplementation in the prevention of anemia in infants.
To evaluate the effectiveness of universal prophylactic targeting with iron sulfate on daily or weekly basis in the prevention of anemia in infants. ⋯ Universal supplementation with iron sulfate from six to 12 months of age was effective in increasing serum Hb and decreasing risk of anemia only when administered on a daily basis.
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Revista de saúde pública · Jun 2005
Randomized Controlled Trial Comparative StudyReactogenicity of yellow fever vaccines in a randomized, placebo-controlled trial.
To compare the reactogenicity of three yellow fever (YF) vaccines from WHO-17D and Brazilian 17DD substrains (different seed-lots) and placebo. ⋯ The frequency of adverse events post-immunization against YF, accounting for the background occurrence of nonspecific signs and symptoms, was shown for the first time to be similar for vaccines from 17D and 17DD substrains. The data also provided evidence against viscerotropism of vaccine virus.
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Revista de saúde pública · Oct 2004
Randomized Controlled Trial Comparative Study Clinical TrialImmunogenicity of WHO-17D and Brazilian 17DD yellow fever vaccines: a randomized trial.
To compare the immunogenicity of three yellow fever vaccines from WHO-17D and Brazilian 17DD substrains (different seed-lots). ⋯ The equivalent immunogenicity of yellow fever vaccines from the 17D and 17DD substrains was demonstrated for the first time in placebo-controlled double-blind randomized trial. The study completed the clinical validation process of a new vaccine seed-lot, provided evidence for use of alternative attenuated virus substrains in vaccine production for a major manufacturer, and for the utilization of the 17DD vaccine in other countries.