Articles: trauma.
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Intestinal ischemia and reperfusion (intestinal I/R) causes acute lung inflammation that is characterized by leukocyte migration, increased lung microvascular permeability, and, in severe forms, noncardiogenic pulmonary edema and acute respiratory distress syndrome. Female sex hormones interfere with immune response, and experimental and clinical evidence shows that females are more resistant than males to organ injury caused by gut trauma. To reduce the lung inflammation caused by intestinal I/R, we have acutely treated male rats with estradiol. ⋯ The treatment with E2 did not affect NOx concentration. Taken together, our data suggest that estradiol modulates the lung inflammatory response induced by lung injury, likely by acute effects. Thus, acute estradiol treatment could be considered as a potential therapeutic agent in ischemic events.
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Thoracic Surgery PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: The aim of this study was to establish the incidence of pulmonary contusion, using our database. ⋯ The following authors have nothing to disclose: Ivan NovakovNo Product/Research Disclosure Information.
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Bronchology Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Bronchopleural fistulas (BPF) have been a known complication of lung resection as well as trauma for many decades. Often times surgical correction is required, however, in certain cases surgery is not a feasible option. ⋯ The following authors have nothing to disclose: Joshua Jewell, Manoj MathewNo Product/Research Disclosure Information.
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Pediatric emergency care · Mar 2014
Comparative StudySeasonal variation of presentation for headache in a pediatric emergency department.
Headache is a common pediatric complaint. Our experience indicated that there was a seasonal variation in children seeking emergency department (ED) care for headache. We hypothesized that visits to the ED would be more common during the school year compared with that during the summer months. ⋯ Visits to the ED for headache were less common in May and June and more common during the fall. This remained true across headache type, age, sex, and racial groups.
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Journal of neurotrauma · Feb 2014
Blockage of the Upregulation of Voltage-Gated Sodium Channel Nav1.3 Improves Outcomes after Experimental Traumatic Brain Injury.
Excessive active voltage-gated sodium channels are responsible for the cellular abnormalities associated with secondary brain injury following traumatic brain injury (TBI). We previously presented evidence that significant upregulation of Nav1.3 expression occurs in the rat cortex at 2 h and 12 h post-TBI and is correlated with TBI severity. In our current study, we tested the hypothesis that blocking upregulation of Nav1.3 expression in vivo in the acute stage post-TBI attenuates the secondary brain injury associated with TBI. ⋯ The Morris water maze memory retention test showed that both the aCSF and ODN groups took longer to find a hidden platform, compared with the sham group (p<0.01). However, latency in the aCSF group was significantly higher than in the ODN group (p<0.05). Our in vivo Nav1.3 inhibition studies suggest that therapeutic strategies to block upregulation of Nav1.3 expression in the brain may improve outcomes following TBI.