Articles: pain-measurement.
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Reg Anesth Pain Med · Feb 2025
Review Meta AnalysisPrevalence of and recommendation for measuring chronic postsurgical pain in children: an updated systematic review and meta-analysis.
According to the prior 2017 review (Rabbitts et al), approximately 20% of children and adolescents develop chronic postsurgical pain (CPSP; ie, pain persisting >3 months after surgery) after major surgeries, which is associated with adverse functional and psychological consequences. A major barrier was that definitions of CPSP applied were highly variable. Since that prior review was conducted (n=4 studies in meta-analysis), numerous relevant studies have been published warranting an update. ⋯ CRD42022306340.
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Reg Anesth Pain Med · Feb 2025
ReviewRecognizing pain phenotypes: biopsychosocial sources of variability in the transition to chronic postsurgical pain.
Chronic postsurgical pain (CPSP) is a cause of new chronic pain, with a wide range of reported incidence. Previous longitudinal studies suggest that development of CPSP may depend more on the constellation of risk factors around a patient (pre-existing pain phenotype) rather than on the extent of surgical injury itself. The biopsychosocial model of pain outlines a broad array of factors that modulate the severity, longevity, and impact of pain. ⋯ Early preoperative identification of a patient's pain phenotype allows estimation of their constellation of risk factors and may greatly enhance successful, personalized prevention of postoperative pain. Effective preoperative employment of behavioral interventions like cognitive-behavioral therapy, stress reduction, and physical and mental prehabilitation may particularly require knowledge of a patient's pain phenotype. Preoperative assessment of patients' pain phenotypes will not only inform high-quality personalized perioperative care clinically, but it will enable enriched testing of novel therapies in future scientific studies.
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Reg Anesth Pain Med · Feb 2025
ReviewInnovations in acute and chronic pain biomarkers: enhancing diagnosis and personalized therapy.
Pain affects millions worldwide, posing significant challenges in diagnosis and treatment. Despite advances in understanding pain mechanisms, there remains a critical need for validated biomarkers to enhance diagnosis, prognostication, and personalized therapy. This review synthesizes recent advancements in identifying and validating acute and chronic pain biomarkers, including imaging, molecular, sensory, and neurophysiological approaches. ⋯ Rigorous validation and standardization efforts are also necessary to ensure these biomarkers are clinically useful. Large-scale collaborative research will be vital to driving progress in this field and implementing these biomarkers in clinical practice. This comprehensive review highlights the potential of biomarkers to transform acute and chronic pain management, offering hope for improved diagnosis, treatment personalization, and patient outcomes.
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J Pain Symptom Manage · Feb 2025
ReviewValidation of Pediatric Self-Report Pain Scales in Sub-Saharan Africa: A Systematic Review.
Pediatric self-report pain scales must be validated in cultural/language contexts to provide optimal pain management. Sub-Saharan Africa included vast numbers of people groups, cultures, and languages. ⋯ 5 countries in Sub-Saharan Africa have a self-report pediatric pain scale validated in their national language/context. Validation methods varied widely from qualitative to quantitative, including convergent, discriminant and face validity. Given the burden of pediatric pain in sub-Saharan Africa, further work is required to provide culturally appropriate and language-specific pain tools.
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Intensive care medicine · Jan 2025
The association between pain, analgesia, and delirium among critically ill adults: a systematic review and meta-analysis.
We performed a systematic review with meta-analysis examining the relationship between pain or pain medications and delirium occurence, duration, and severity. ⋯ We observed an association between pain and incident delirium among critically ill adults. Exposure to morphine or fentanyl (but no other pain medications) was associated with increased risk of delirium occurrence.