Articles: nerve-block.
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Randomized Controlled Trial Clinical Trial
Study of the effectiveness of bupivicaine infiltration of the ilioinguinal nerve at the time of hernia repair for post-operative pain relief.
The effect on post-operative pain relief and analgesic requirements of direct ilioinguinal nerve block using 0.5% bupivicaine (Marcain) at the time of hernia repair was studied. Sixty patients were randomly allocated into two groups, A and B, both being well matched for age, numbers and sex. Those in whom nerve block was used (Group A) required significantly less intramuscular opiates and strong oral analgesics (co-dydramol) than those who did not receive bupivicaine (Group B) during the first 24 hours post-operatively.
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J Pain Symptom Manage · Jun 1989
Randomized Controlled Trial Comparative Study Clinical TrialEvaluation of neurolytic blocks using phenol and cryogenic block in the management of chronic pain.
This study compared the use of phenol and cryogenic blocks for neurolysis in 28 patients. Patients were assigned randomly to receive peripheral nerve blocks with either phenol or cryoanalgesia. Significantly more patients in the phenol group received 20% or greater relief at 2, 12, and 24 wk than patients in the cryogenic group. Only 27% of patients received significant relief, however, indicating that neurolytic blocks were not particularly effective even though local anesthetic blocks produced significant but temporary pain relief.
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Randomized Controlled Trial Clinical Trial
Alkalinisation of bupivacaine for sciatic nerve blockade.
This double-blind study investigates the effect of pH adjustment of bupivacaine 0.5% with adrenaline 1:200,000 on block latency, duration of analgesia and systemic absorption of local anaesthetic after sciatic nerve blockade. Twenty-four adult patients were randomly allocated into one of two groups: Group A (n = 12) received bupivacaine with adrenaline 1:200,000 (pH 3.9) 2 mg/kg, while Group B (n = 12) received alkalinised bupivacaine with adrenaline 1:200,000 (pH 6.4) 2 mg/kg. ⋯ There was no significant difference in plasma bupivacaine levels between the two groups. The results indicate that alkalinisation of bupivacaine reduces time to onset and prolongs the duration of useful analgesia when used for sciatic nerve blockade, without significantly increasing systemic absorption.
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Randomized Controlled Trial Comparative Study Clinical Trial
Bupivacaine: a safe local anesthetic for wrist blocks.
Seventy-one patients having minor hand surgical procedures under wrist block anesthesia were studied, with the goal of identifying a possible neurotoxic potential of bupivacaine when used according to standard clinical practice. This drug was compared with lidocaine at equipotent analgesic concentrations (bupivacaine: 5 mg/ml; lidocaine: 20 mg/ml) by use of a double-blind randomized protocol. ⋯ In the remaining patient, anesthesia was induced with lidocaine, and no cause could be identified. It was concluded that bupivacaine, when used in clinical concentrations, is not associated with an increased incidence of neural complications.
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J Am Podiatr Med Assoc · Mar 1989
Randomized Controlled Trial Clinical TrialThermographic evaluation of the autonomic effects of nerve blocks in the foot.
The authors evaluated regional skin temperatures of the foot following the administration of a variety of local anesthetic nerve blocks with either Xylocaine (lidocaine hydrochloride) or Sensorcaine (bupivacaine hydrochloride). The study was carried out on ten randomized parallel groups of five subjects, each group being tested with one drug and one regional nerve block. The results indicated that both Xylocaine and Sensorcaine, when administered as a posterior tibial block, result in a significantly increased blood flow to the foot. Nerve blockade of the remaining nerves of the foot did not significantly increase the sympatholytic effect obtained by posterior tibial nerve block alone.