Articles: chronic.
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Telemedicine PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: To determine if an early assisted discharge program for chronic obstructive pulmonary disease (COPD) exacerbations, with telemonitoring and telephone control, is equally effective and more efficient in terms of use of health care resources, that a home care provided by hospital department respiratory ⋯ The following authors have nothing to disclose: Patricia Mínguez, Beatriz Cadavid, Carmen Mata, Rosa Malo, Miriam Aguilar, Manuel Valle, Andrea Trisan, Antolín Lopez, Mario Pascual, Juan Fragua, Piedad UssettiNo Product/Research Disclosure Information.
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Pulmonary Function TestingSESSION TYPE: Slide PresentationsPRESENTED ON: Sunday, March 23, 2014 at 04:15 PM - 05:15 PMPURPOSE: According to the predominant phenotype, patients suffering from Chronic Obstructive Pulmonary Oisease (COPO) may present varying and important nutritional profile alterations, up to extreme degrees of severe proteic-energetic malnutrition. In our study, Bioelectricallmpedance Analysis (BIA) has been used in the evaluation of nutritional status (with particular regards to body lean mass alterations) of patients suffering from COPDMETHODS: Up to now, 68 patients (46 M; mean age 70.6 yrs) affected by stable mild to very severe COPD (GOLD 2011 stages l-IV) were evaluated. All of them underwent body plethysmographic evaluation of pulmonary function, six-minute walking test (6MWT) and respiratory muscles strength evaluation (with maximum Inspiratory and expiratory pressures - MIP/MEP - assessment). Moreover, BIA variables were studied with Dietosystem Human Scan, that expresses either quantitative (BIA index) and qualitative (multifrequency relation and phase angle) body lean mass alterations. Furthermore, SIA data from a control age matched group were collected. ⋯ The following authors have nothing to disclose: Francesco De Blasio, Maria Grazia Santaniello, Francesca De Blasio, Giulia Miracco Berlingieri, Barbara Bellofiore, Luca ScalfiNo Product/Research Disclosure Information.
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Pulmonary and Sleep MedicineSESSION TYPE: Slide PresentationPRESENTED ON: Saturday, March 22, 2014 at 09:00 AM - 10:00 AMPURPOSE: Intermittent hypoxia and increase sympathetic activity during apnea episodes may cause systemic inflammation via down-regulation of regulatory T-cell (Treg cells). This may contribute to premature atherosclerosis leading to an increase in the size of arterial intima-media thickness (IMT). To evaluate the relationship between Treg plasma cells and intima-media thickness (IMT) in non-OSA and OSA patients without comorbidities ⋯ The effect of nocturnal intermittent hypoxia and increase sympathetic activity is not homogeneous among all patients with OSA. It seems that a subset of patients exhibit an increased risk of subclinical atherosclerosis associated with a down-regulation of regulatory T-cells. This subgroup of patients probably represents a particular phenotypic presentation of OSA that merits a specific treatment. Supported by ISCIII grant PI12/02175 and SEPAR-2014DISCLOSURE: The following authors have nothing to disclose: Marta Marin-Oto, Teresa Martin, Javier Godino, Marta Andres, Victoria Gil, Jose MarinNo Product/Research Disclosure Information.
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Cancer Case Report Posters ISESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMPURPOSE: Lymphoproliferative disorders(LPD) are common in immunosuppressed patients and in patients with connective tissue disorders(CTD). There is increased risk in Sjögren's syndrome(SS) and moderate risk in systemic lupus erythematosis(SLE). ⋯ The following authors have nothing to disclose: Shraddha Goyal, Adnan Abbasi, Pratibha Kaul, Fatme AllamNo Product/Research Disclosure Information.
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Reg Anesth Pain Med · Mar 2014
Ghrelin Alleviates Neuropathic Pain Through GHSR-1a-Mediated Suppression of the p38 MAPK/NF-κB Pathway in a Rat Chronic Constriction Injury Model.
Neuropathic pain is related to the sustained activation of neuroglial cells and the production of proinflammatory cytokines in the spinal dorsal horn. Ghrelin, the endogenous ligand for growth hormone secretagogue receptor 1a (GHSR-1a), has been shown to inhibit the activation of microglia and the release of proinflammatory cytokines. The purpose of this study was to investigate the role of ghrelin/GHSR-1a signaling in neuropathic pain and to understand the associated mechanisms. ⋯ Our present study demonstrated that ghrelin alleviated neuropathic pain through a GHSR-1a-mediated suppression of the p38 MAPK/NF-κB pathway.