Articles: chronic.
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Clinical Trial
Percutaneous Nerve Stimulation in Chronic Neuropathic Pain Patients due to Spinal Cord Injury: A Pilot Study.
The long-term prognosis for neuropathic pain resolution following spinal cord injury (SCI) is often poor. In many SCI patients, neuropathic pain continues or even worsens over time. Thus, new treatment approaches are needed. We conducted a pilot study to evaluate the feasibility and effect of percutaneous (electrical) nerve stimulation (P(E)NS) in SCI patients with chronic neuropathic pain. ⋯ P(E)NS is feasible as an intervention in SCI patients and might have a positive effect on pain reduction in a part of this patient group.
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Long-term Prognosis of Chronic Obstructive Pulmonary Disease (COPD) Patients on Home Oxygenotherapy.
COPD PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Our objective has been to assess the survival of a cohort of COPD patients in HO program and to investigate the main causes of mortality between these patients. ⋯ The following authors have nothing to disclose: María del Carmen García García, Jacinto Hernández Borge, Pedro Pires Goncalves, Carlos Antonio Aranda López, Lourdes Cañón Barroso, Estefanía Molina Ortiz, Amparo Sanz Cabrera, José Antonio Gutierrez Lara, María Teresa Gómez Vizcaíno, Ignacio Rodríguez BlancoNo Product/Research Disclosure Information.
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Mortality after lower limb amputation is high, with UK 30-day mortality rates of 9-17%. We performed a retrospective analysis of factors affecting early and late outcome after lower limb amputation for peripheral vascular disease or diabetic complications at a UK tertiary referral vascular centre between 2003 and 2010. Three hundred and thirty-nine patients (233 male), of median (IQR [range]) age 73 (62-79 [26-92]) years underwent amputation. ⋯ Anaesthetic technique was associated with long-term mortality on survival analysis (p = 0.04), but not when analysed using regression modelling. Mortality after lower limb amputation relates to patient age, ASA, out-of-hours surgery and renal dysfunction. These data support lower limb amputations' being performed during daytime hours and after modification replace with 'of ' correctable risk factors.
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Reg Anesth Pain Med · Mar 2014
Ghrelin Alleviates Neuropathic Pain Through GHSR-1a-Mediated Suppression of the p38 MAPK/NF-κB Pathway in a Rat Chronic Constriction Injury Model.
Neuropathic pain is related to the sustained activation of neuroglial cells and the production of proinflammatory cytokines in the spinal dorsal horn. Ghrelin, the endogenous ligand for growth hormone secretagogue receptor 1a (GHSR-1a), has been shown to inhibit the activation of microglia and the release of proinflammatory cytokines. The purpose of this study was to investigate the role of ghrelin/GHSR-1a signaling in neuropathic pain and to understand the associated mechanisms. ⋯ Our present study demonstrated that ghrelin alleviated neuropathic pain through a GHSR-1a-mediated suppression of the p38 MAPK/NF-κB pathway.
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Cancer Case Report Posters IISESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Inflammatory psedotumor of the lung is a rare, quasineoplastic lung tumor of unknown etiology. It occurs most often in young adults ⋯ Although pulmonary inflammatory pseudotumors are considered benign, they can be very aggressive locally or cause metastasis. The differential diagnosis is usually with lung cancer and the deffinitive diagnosis is made on histopathological exam. If possible, complete surgical resection is necessary and can cure the disease. Extended follow-up is required in these patients.Reference #1: Surgical management of pulmonary inflammatory pseudotumors: a single center experience. Mondello B, Lentini S, Barone M, Barresi P, Monaco F, Familiari D, La Rocca A, Sibilio M, Acri IE, David A, Monaco M. J Cardiothorac Surg. 2011 Feb 23;6:18. doi: 10.1186/1749-8090-6-18. PMID:21345228DISCLOSURE: The following authors have nothing to disclose: Ionela Belaconi, Claudia Toma, Stefan Dumitrache-Rujinski, Alina Croitoru, Miron BogdanNo Product/Research Disclosure Information.