Articles: linear-models.
-
Clin J Am Soc Nephrol · Mar 2020
Multicenter StudyParticulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKD.
Exposure to particulate matter (PM) <2.5 μm in aerodynamic diameter (PM2.5) has been linked to detrimental health effects. This study aimed to describe the relationship between long-term PM2.5 exposure and kidney disease, including eGFR, level of albuminuria, and incident CKD. ⋯ Exposure to higher annual average PM2.5 concentrations was associated with a higher level of albuminuria and higher risk for incident CKD in a community-based cohort.
-
Journal of neurotrauma · Sep 2019
Multicenter Study Observational StudyUnbiased Recursive Partitioning to Stratify Patients With Acute Traumatic Spinal Cord Injuries: External Validity in an Observational Cohort Study.
Clinical trials of novel therapies for acute spinal cord injury (SCI) are challenging because variability in spontaneous neurologic recovery can make discerning actual treatment effects difficult. Unbiased Recursive Partitioning regression with Conditional Inference Trees (URP-CTREE) is a novel approach developed through analyses of a large European SCI database (European Multicenter Study about Spinal Cord Injury). URP-CTREE uses early neurologic impairment to predict achieved motor recovery, with potential to optimize clinical trial design by optimizing patient stratification and decreasing sample sizes. ⋯ A previous URP-CTREE model had limited ability to stratify an independent into homogeneous subgroups. Overall accuracy was promising, but may be sensitive to timing of baseline neurological examinations. Further evaluation of external validity in incomplete injuries, influence of timing of baseline examinations, and investigation of additional stratification strategies is warranted.
-
Randomized Controlled Trial Multicenter Study
Who Benefits Most from Individualized Physiotherapy or Advice for Low Back Disorders? A Pre-Planned Effect Modifier Analysis of a Randomized Controlled Trial.
A preplanned effect modifier analysis of the Specific Treatment of Problems of the Spine randomized controlled trial. ⋯ 2.
-
Multicenter Study Observational Study
Anterior Trunk Mobility Does Not Predict Disability in Elderly Women with Acute Low Back Pain: Brazilian Back Complaints in the Elders (BACE-Brazil) Study Results.
Cross-sectional, ancillary study of an international multicenter epidemiological study. ⋯ N/A.
-
Multicenter Study
The relative contribution of provider and ED-level factors to variation among the top 15 reasons for ED admission.
We examine adult emergency department (ED) admission rates for the top 15 most frequently admitted conditions, and assess the relative contribution in admission rate variation attributable to the provider and hospital. ⋯ For different conditions, there were different contributions to variation at the hospital- and provider-level. These findings deserve consideration when designing interventions to optimize admission decisions and in value-based payment programs.