Articles: oligonucleotide-array-sequence-analysis.
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Editorial Comment
Application of genomic technology in prenatal diagnosis.
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Accurate diagnostic tests are essential for the correct identification of etiologic agents causing sepsis. Conventional microbiology cultures are time consuming and may even yield negative results in many cases of septic shock. In this manner, molecular-based technologies are emerging as promising tests for use into routine clinical laboratories. ⋯ Results of studies using polymerase chain reaction, real-time polymerase chain reaction, and complementary DNA/oligonucleotide microarrays are described and discussed into the current scenario. These new methodologies are able to detect even small amounts of bacterial DNA directly from blood specimens and show increased sensitivity and specificity for detecting many infectious agents associated with sepsis. Despite some limitations presented by nucleic acid-based techniques, these genotypic tests can be useful along with traditional microbiology diagnostics.
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Editorial Comment
"A razor may be sharper than an ax, but it cannot cut wood".
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Is biological research ready for the new wave of data-reporting standards currently under development?