Articles: blood-glucose-analysis.
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Br Med J (Clin Res Ed) · Mar 1985
Randomized Controlled Trial Clinical TrialRapid tightening of blood glucose control leads to transient deterioration of retinopathy in insulin dependent diabetes mellitus: the Oslo study.
In a study of retinopathy during one year of tight blood glucose control 45 type I (insulin dependent) diabetics without proliferative retinopathy were randomised to receive either continuous subcutaneous insulin infusion, multiple insulin injections, or conventional insulin treatment (controls). Near normoglycaemia was achieved with continuous infusion and multiple injections but not with conventional treatment. Blind evaluation of fluorescein angiograms performed three monthly showed progression of retinopathy in the control group, transient deterioration in the continuous infusion group, and no change in the multiple injection group. ⋯ Control patients did not develop cotton wool spots. Patients who developed cotton wool spots are characterised by a larger decrement in glycosylated haemoglobin and blood glucose values, more frequent episodes of hypoglycaemia, a longer duration of diabetes, and more severe retinopathy at onset. A large and rapid fall in blood glucose concentration may promote transient deterioration of diabetic retinopathy.
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Serial blood glucose estimations were made in 30 women undergoing elective Caesarean section under epidural anaesthesia, 2 litres of Hartmann's solution having been rapidly infused as a circulatory preload Neonatal blood glucose estimations were made of cord blood at birth and 1 and 2 hours post delivery. A small rise in maternal blood glucose occurred during the period of preloading and time before delivery, which was not statistically significant (p greater than 0.05). There was no biochemical or clinical evidence of neonatal hypoglycaemia. We conclude that despite rapid infusion of non-dextrose crystalloid solution there is neither danger of a relative maternal hypoglycaemia in fasted mothers nor neonatal hypoglycaemia, and offer an argument that even small amounts of dextrose contained in any preloading mixture are unnecessary.
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Randomized Controlled Trial Comparative Study Clinical Trial
Serum glucose levels during long-term observation of treated and untreated men with mild hypertension. The Oslo study.
Serum glucose levels, triglyceride levels, and body weight are reported from a controlled drug trial in men, aged 40 to 49, with uncomplicated mild hypertension. The drug treatment started with hydrochlorothiazide alone, and methyldopa was added when necessary. If side effects occurred, methyldopa was replaced by propranolol. ⋯ There was no difference in serum potassium levels in the different drug groups. The results indicate that moderate thiazide doses do not have significant effects on serum glucose levels in this age group. Propranolol in combination with thiazide seems to increase the level of serum glucose.
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Problemy e̊ndokrinologii · May 1984
[Prevalence of diabetes mellitus and disordered glucose tolerance in persons of working age (a 1-step population study)].
Representative, accidentally selected men and women, living in one of the Moscow regions, were examined, comprising in total 2468 persons: 1225 males and 1243 females. An analysis of the data obtained has shown that the real diabetes mellitus prevalence among persons of 20 to 69 years old is 1.64 to 4.01 times as high as that of registered patients, being 2.01 times as high in females and having several age-sex specific features.