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Randomized Controlled Trial
Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study.
In the general population, increased adiposity is a significant risk factor for colorectal cancer (CRC), but whether obesity has similar effects in those with hereditary CRC is uncertain. This prospective study investigated the association between body mass index and cancer risk in patients with Lynch syndrome (LS). ⋯ Obesity is associated with substantially increased CRC risk in patients with LS, but this risk is abrogated in those taking aspirin. Such patients are likely to benefit from obesity prevention and/or regular aspirin.
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Il Giornale di chirurgia · Sep 1993
Randomized Controlled Trial Comparative Study Clinical Trial[Perioperative pain and stress: a comparison between video laparoscopic cholecystectomy and "open" cholecystectomy].
Pain and endocrine-metabolic response to surgical stress, during surgery and in the early postoperative period, was compared in two groups of patients affected by gallstones and randomly assigned to Laparoscopic Cholecystectomy or Open Cholecystectomy. Pain was assessed by the VAS method also taking into account the need of analgesic administration in the postoperative period. ⋯ In the intraoperative period laparoscopic cholecystectomy plasma hormone levels overlapped the open cholecystectomy ones, while in the postoperative period a constant increase in PRL and CORT levels was registered in the open cholecystectomy group demonstrating a prolonged stressful condition. The end results of this study show that laparoscopic cholecystectomy has major advantages than open cholecystectomy in the treatment of gallstones as far as pain and endocrine-metabolic response are concerned.
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Complement Ther Med · Jan 2011
Randomized Controlled Trial Comparative StudyComparison of biomechanical properties between acupuncture and non-penetrating sham needle.
A non-penetrating sham needle has been considered as a reliable control treatment in the field of acupuncture research. However, some concerns with regard to the credibility of sham needles have also been raised. We investigated whether there were differences in biomechanical properties and acupuncture sensation ratings in the process of needling between verum acupuncture (VA) and sham acupuncture (SA). ⋯ Our findings demonstrate that differential biomechanical forces such as insertion and pullout force contribute to the sensation of real and non-penetrating sham needles.
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Lasers in medical science · Jul 2009
Randomized Controlled Trial Comparative StudyA clinical comparison of topical piroxicam and EMLA cream for pain relief and inflammation in laser hair removal.
The aim of this study was to compare the efficacy of topical piroxicam and EMLA cream on pain control and subsequent inflammation in neodymium:yttrium-aluminum-garnet (Nd:YAG) 1,064 nm laser hair removal in female volunteers. Fifty female volunteers were enrolled in this prospective, randomized, double-blind, clinical study over a 6-month period. Patients were randomly assigned to receive topical piroxicam as group Piroxicam or EMLA cream as group EMLA. ⋯ Inflammatory side effects were less frequent in group P than in group E after the procedure (P < 0.001). This study showed that topical piroxicam and EMLA provided adequate and similar pain relief after Nd:YAG 1,064 nm laser hair removal in female volunteers. Topical piroxicam was associated with fewer inflammatory side effects than was EMLA cream, because of its anti-inflammatory effect after the procedure.
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J. Allergy Clin. Immunol. · May 1999
Randomized Controlled Trial Clinical TrialIn vivo effect of albuterol on methacholine-contracted bronchi in conjunction with salmeterol and formoterol.
It has been shown in vitro that prior treatment with salmeterol and formoterol antagonizes the relaxant effect of albuterol in carbachol-contracted human bronchi. ⋯ Compared with placebo, both salmeterol and formoterol caused a significant degree of antagonism of albuterol-induced bronchorelaxation in methacholine-contracted bronchi in vivo. This interaction could be caused by prolonged occupancy of airway beta2-adrenoceptors by long-acting beta2-agonists or by early tachyphylaxis 12 hours after a single-dose exposure. The degree of albuterol protection was also related to beta2-adrenoceptor polymorphism.