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Review Meta Analysis
Prevalence of serious mental disorder in 7000 refugees resettled in western countries: a systematic review.
About 13 million people are classified as refugees worldwide, and many more former refugees have been granted citizenship in their new countries. However, the prevalence of post-traumatic stress disorder, major depression, or psychotic illnesses in these individuals is not known. We did a systematic review of surveys about these disorders in general refugee populations in western countries. ⋯ Refugees resettled in western countries could be about ten times more likely to have post-traumatic stress disorder than age-matched general populations in those countries. Worldwide, tens of thousands of refugees and former refugees resettled in western countries probably have post-traumatic stress disorder.
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Int. J. Immunogenet. · Oct 2010
Meta AnalysisAssociation of SUMO4 M55V polymorphism with susceptibility to autoimmune and inflammatory diseases: a meta-analysis.
The purpose of this study was to generate large-scale evidence on whether SUMO4 M55V polymorphism is associated with autoimmune and inflammatory diseases using a meta-analysis. We surveyed studies on the association of SUMO4 M55V polymorphism with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed for genotypes AG versus AA, GG versus AA, GG versus AA + AG, AG + GG versus AA and G allele versus A allele in a fixed/random effect model. ⋯ But the association was not found in Caucasian population. Meanwhile, an association of SUMO4 M55V polymorphism with autoimmune diabetes was found (G versus A: OR=1.18, 95%CI=1.08-1.30, P=0.0005; AG+GG versus AA: OR=1.22, 95%CI=1.13-1.32, P<0.00001; GG versus AA+AG: OR=1.15, 95%CI=0.96-1.38, P=0.13; GG versus AA: OR=1.32, 95%CI=1.08-1.60, P=0.006; AG versus AA: OR=1.23, 95%CI=1.13-1.33, P<0.00001). This meta-analysis demonstrates the association of SUMO4 M55V polymorphism with autoimmune and inflammatory diseases, especially in Asian population.
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Review Meta Analysis
Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies.
Studies have sought associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol-dependence, but findings are inconsistent. We summarize the information as to associations of rs1799971 (A > G) and the alcohol-dependence. ⋯ The rs1799971 (A > G) is not strongly associated with alcohol-dependence. However, there are study heterogeneities and limited sample sizes.
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Nesiritide improves symptoms in patients with acutely decompensated heart failure compared with placebo and appears to be safer than dobutamine. Its short-term safety relative to standard diuretic and vasodilator therapies is less clear. ⋯ Compared with noninotrope-based control therapy, nesiritide may be associated with an increased risk of death after treatment for acutely decompensated heart failure. The possibility of an increased risk of death should be investigated in a large-scale, adequately powered, controlled trial before routine use of nesiritide for acutely decompensated heart failure.
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Eur. J. Cancer Prev. · May 2011
Meta AnalysisEpidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis.
Many in-vitro and animal studies have provided evidence that tea has many possible anticarcinogenic mechanisms, but epidemiological evidence for the effect of tea consumption on the primary liver cancer risk remains controversial and, to date, there have been no quantitative meta-analyses reported regarding this topic. The aim of this meta-analysis is to evaluate the association between tea consumption and the risk of primary liver cancer from case-control and cohort studies. Epidemiological studies of tea consumption in relation to primary liver cancer were identified by searching MEDLINE, EMBASE, Chinese Bio-medicine Database, and Chinese Wanfang Database, from January 1979 to December 2009. ⋯ No publication bias was found either from funnel plot visualization or the Egger-weighted regression (P value = 0.34) and the Begg rank correlation (P value = 0.12) methods. These results provide more evidence for a protective effect of tea consumption against the development of primary liver cancer. More well-conducted and large-scale epidemiological studies are needed.