Trending Articles
-
Paediatric anaesthesia · Mar 2006
Randomized Controlled TrialThe efficacy of caudal morphine or bupivacaine combined with general anesthesia on postoperative pain and neuroendocrine stress response in children.
The aim of this study was to compare the effectiveness of caudal morphine and bupivacaine usage on surgical stress response in children undergoing abdominal and genitourinary surgery while keeping anesthesia depth constant utilizing the bispectral index analysis (BIS). ⋯ We conclude that, caudal administration of bupivacaine is more effective than morphine for attenuating intraoperative and postoperative stress response to surgery in children.
-
Randomized Controlled Trial Multicenter Study Comparative Study
Cost-effectiveness of laparoscopic fundoplication versus continued medical management for the treatment of gastro-oesophageal reflux disease based on long-term follow-up of the REFLUX trial.
Laparoscopic fundoplication surgery has been shown to be a cost-effective alternative to continued medical management over 1 year for patients with gastro-oesophageal reflux disease (GORD). The longer-term cost-effectiveness is, however, uncertain. This study evaluated the long-term health benefits, costs and cost-effectiveness of laparoscopic fundoplication compared with continued medical management in patients with GORD. ⋯ Laparoscopic fundoplication is a cost-effective alternative to continued medical management over 5 years. No evidence was found to suggest that the cost-effectiveness of laparoscopic fundoplication diminishes over time.
-
Randomized Controlled Trial
A randomized trial of antibiotic prophylaxis for the prevention of surgical site infection after open mesh-plug hernia repair.
The efficacy of antibiotic prophylaxis for the prevention of surgical-site infection (SSI) after open tension-free inguinal hernia repair remains controversial. ⋯ This study indicates that antibiotic prophylaxis is effective for the prevention of SSI after open mesh-plug hernia repair.
-
Randomized Controlled Trial Comparative Study
Randomized clinical trial of stapled haemorrhoidopexy performed under local perianal block versus general anaesthesia.
The aim was to assess the feasibility of performing stapled haemorrhoidopexy under local anaesthesia. ⋯ ISRCTN19930199 (http://www.controlled-trials.com).
-
Anesthesia and analgesia · Dec 1996
Randomized Controlled Trial Clinical TrialDroperidol/ondansetron combination controls nausea and vomiting after tubal banding.
The antiemetic activity of droperidol is attributed to antagonizing the dopaminergic neurons of the chemoreceptor trigger zone. Ondansetron is a serotonin (5HT) receptor antagonist at both peripheral and central 5-HT3 receptor sites with no known action on dopamine-mediated activity. We hypothesized that the combination of these two antiemetics would be more effective than droperidol alone. ⋯ There were seven emetic episodes in five patients in Group 1 and 30 emetic episodes in 12 patients in Group 2 over the 24-h study period (P = 0.03). The time to the first emetic episode was more than twice as long for Group 1 than Group 2 (P = 0.03) and total nausea scores were lower in Group 1 than Group 2 (P = 0.01). The droperidol/ondansetron combination was significantly superior to droperidol in complete response, time to and number of emetic episodes, and the incidence and severity of nausea in women having tubal banding.