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J Am Acad Child Adolesc Psychiatry · Dec 2009
Randomized Controlled Trial Multicenter Study Comparative StudyMedication and parent training in children with pervasive developmental disorders and serious behavior problems: results from a randomized clinical trial.
Many children with pervasive developmental disorders (PDDs) have serious, functionally impairing behavioral problems. We tested whether combined treatment (COMB) with risperidone and parent training (PT) in behavior management is superior to medication alone (MED) in improving severe behavioral problems in children with PDDs. ⋯ Medication plus PT resulted in greater reduction of serious maladaptive behavior than MED in children with PDDs, with a lower risperidone dose.
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Randomized Controlled Trial Multicenter Study
Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder: a randomized controlled trial.
Men with overactive bladder and other lower urinary tract symptoms may not respond to monotherapy with antimuscarinic agents or alpha-receptor antagonists. ⋯ These results suggest that treatment with tolterodine ER plus tamsulosin for 12 weeks provides benefit for men with moderate to severe lower urinary tract symptoms including overactive bladder. Clinical Trials Registration clinicaltrials.gov Identifier: NCT00147654.
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J. Gerontol. A Biol. Sci. Med. Sci. · Aug 2012
Multicenter StudyHospital readmission in persons with stroke following postacute inpatient rehabilitation.
Readmission is an important quality indicator following acute care hospitalization. We examined factors associated with hospital readmission in persons with stroke following postacute inpatient rehabilitation. ⋯ Functional status, depressive symptoms, and social support were important predictors of hospital readmission. These variables are not included in most administrative data sets. Future research to develop useful risk-adjustment models for rehospitalization following postacute inpatient rehabilitation services should include large diverse samples and explore practical sources for additional meaningful information.
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Multicenter Study Clinical Trial
A long-term open-label study of oral almotriptan 12.5 mg for the treatment of acute migraine.
Evaluate the long-term tolerability of almotriptan 12.5 mg for the treatment of acute migraine attacks occurring over a 6-month period. ⋯ When taken at attack onset, almotriptan 12.5 mg is well tolerated, safe, and effective for the long-term treatment of acute migraine.
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Multicenter Study Clinical Trial
A 21-week open-label clinical trial of pregabalin as adjunctive therapy in partial seizures at multiple centers in Mexico (PREPS Mexico).
To investigate the efficacy of pregabalin in the treatment of refractory partial seizures. ⋯ Pregabalin was well tolerated and associated with significant reductions in seizure frequency.