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Randomized Controlled Trial Multicenter Study Comparative Study
Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium.
After repeated rocuronium administration there is wide inter-patient variability in the time to recover muscle function.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network.
Traditional approaches to mechanical ventilation use tidal volumes of 10 to 15 ml per kilogram of body weight and may cause stretch-induced lung injury in patients with acute lung injury and the acute respiratory distress syndrome. We therefore conducted a trial to determine whether ventilation with lower tidal volumes would improve the clinical outcomes in these patients. ⋯ In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.
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Randomized Controlled Trial Multicenter Study
Effect of the World Health Organization checklist on patient outcomes: a stepped wedge cluster randomized controlled trial.
Implementing the WHO Safe Surgery Checklist may reduce morbidity, length of stay and mortality, although many questions remain.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group.
To determine whether a restrictive strategy of red-cell transfusion and a liberal strategy produced equivalent results in critically ill patients, we compared the rates of death from all causes at 30 days and the severity of organ dysfunction. ⋯ A restrictive strategy of red-cell transfusion is at least as effective as and possibly superior to a liberal transfusion strategy in critically ill patients, with the possible exception of patients with acute myocardial infarction and unstable angina.
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Anesthesia and analgesia · Aug 2015
Multicenter Study Observational StudyThe RECITE Study: A Canadian Prospective, Multicenter Study of the Incidence and Severity of Residual Neuromuscular Blockade.
Postoperative residual neuromuscular blockade continues to be common and is experienced by the majority of patients receiving muscle relaxants.
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