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Multicenter Study Clinical Trial
Insulin pump therapy for 1-6 year old children with type 1 diabetes.
The management of diabetes in preschool children poses unique difficulties for both the families and the medical team. ⋯ For very young diabetic children, insulin pump therapy improves quality of life and is feasible and safe. It should be considered as an optional mode of therapy for this age group.
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Scand. Cardiovasc. J. · Feb 2010
Multicenter StudyCatheter based closure of ventricular septal defects.
Catheter based treatment for heart diseases is increasing. Rikshospitalet has been the leading force in Norway to introduce such methods. We present the results of such treatment for different defects in the ventricular septum (VSD). ⋯ Catheter-based closure of VSD is a good alternative to open heart surgery. At present our own and the reported incidence of complete AV blocks lead us to be cautious when recommending closure of perimembranous VSD.
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Multicenter Study Comparative Study Observational Study
Practice patterns and outcomes after stroke across countries at different economic levels (INTERSTROKE): an international observational study.
Stroke disproportionately affects people in low-income and middle-income countries. Although improvements in stroke care and outcomes have been reported in high-income countries, little is known about practice and outcomes in low and middle-income countries. We aimed to compare patterns of care available and their association with patient outcomes across countries at different economic levels. ⋯ Chest, Heart and Stroke Scotland.
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Klinische Pädiatrie · Jul 1998
Randomized Controlled Trial Multicenter Study Clinical TrialPrevention of CNS recurrence in childhood ALL: results with reduced radiotherapy combined with CNS-directed chemotherapy in four consecutive ALL-BFM trials.
The introduction of cranial radiotherapy (CRT) has provided efficient control of overt or subclinical meningeosis in acute lymphoblastic leukemia (ALL). Especially due to the long-term toxicity of CRT, reduction or elimination of radiotherapy appeared mandatory after cure rates of more than 70% had been achieved in ALL. The Berlin-Frankfurt-Münster (BFM) Study Group initiated several attempts in certain ALL subgroups to omit or reduce CRT while using more CNS-directed chemotherapy but without extended intrathecal treatment during maintenance therapy. This analysis summarizes the essential results that are in particular relevant because irradiation of the central nervous system (CNS) has been further reduced in the most recent trial ALL-BFM 95. ⋯ Low-risk ALL patients can be efficiently prevented from CNS relapse by intensive systemic and intrathecal chemotherapy without CRT. Patients with intermediate or medium risk ALL, including T-cell ALL, did not suffer from more CNS or systemic relapses when CRT was reduced to only 12 Gy. Patients with inadequate response to therapy are at particularly high risk for relapse with CNS involvement. Therefore, more CNS-directed systemic and intrathecal chemotherapy was applied in trial ALL-BFM 90, combined with only 12 Gy cranial irradiation, and improved the control of CNS recurrence. It seems likely that larger subsets of B-precursor ALL can be protected from CNS-related relapse by intensive chemotherapy without extended IT treatment and without CRT. This is being investigated in the ongoing trial ALL-BFM 95.
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Multicenter Study
Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives.
HER2 mutations are identified in approximately 2%of non-small-cell lung cancers (NSCLC). There are few data available that describe the clinical course of patients with HER2-mutated NSCLC. ⋯ This study, the largest to date dedicated to HER2-mutated NSCLC, reinforces the importance of screening for HER2 mutations in lung adenocarcinomas and suggests the potential efficacy of HER2-targeted drugs in this population.