Trending Articles
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Zhonghua Xue Ye Xue Za Zhi · Apr 2019
[Comparison of umbilical cord blood transplantation and hematopoietic stem cell transplantation from HLA-matched sibling donors in the treatment of myelodysplastic syndrome-EB or acute myeloid leukemia with myelodysplasia-related changes].
Objective: To compare the clinical efficacy of umbilical cord blood transplantation (UCBT) and hematopoietic stem cell transplantation from HLA-matched sibling donors (MSD-HSCT) in the treatment of myelodysplastic syndrome-EB (MDS-EB) or acute myeloid leukemia with myelodysplasia-related changes (AML-MRC). Methods: A cohort of 64 patients (including 38 cases of MDS-EB and 26 cases of AML-MRC) who received UCBT/MSD-HSCT from February 2011 to December 2017 were retrospectively analyzed. ⋯ The cumulative 3-year incidence of GVHD-free and relapse-free survival (GRFS) of UCBT group was significantly higher than of MSD-HSCT group [55.0% (95%CI 36.0%-70.6%) vs 28.6% (95%CI 13.5%-45.6%) , P=0.038]. Conclusion: UCBT could obtain better quality of life after transplantation than MSD-HSCT in treatment of MDS-EB/AML-MRC.
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In the 1960s, the concept of saving lives through the use of cardiopulmonary resuscitation (CPR) was a revolutionary idea. In the 1990s, CPR is a household word, and CPR classes are taught to both medical and nonmedical groups. The layperson is a critical link in the chain of survival for cardiac arrests (1). ⋯ Studies have revealed that bystanders trained in CPR often fail to recognize emergencies and typically delay the initiation of CPR when emergencies are present. A change in the approach to CPR instruction is needed. CPR instructors are encouraged to develop innovative teaching strategies that enhance learning and meet the goal of community CPR training.
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Comparative Study
Unequal Rates of Serious Perioperative Respiratory Adverse Events Between Black and White Children.
Recent data among pediatric otolaryngology patients showed unexplained higher rates of serious perioperative respiratory adverse events (PRAE) in black children compared to their white peers. We evaluated whether preoperative respiratory comorbidity (PRC) burden contributes to racial disparity in serious PRAE in children undergoing non-otolaryngologic procedures. ⋯ Race and PRC are important considerations in the risk of serious PRAE and black children are especially at risk compared to their white peers. Children, with PRC (particularly those with SDB and asthma) are also at risk suggesting that due consideration should be given to these factors in the perioperative care of children undergoing elective surgical procedures. Mechanisms underlying these associations deserve further evaluation.