• Hydroxylethyl starches: harm and acute liver injury

     
       

    Daniel Jolley.

    9 articles.

    Created May 21, 2015, last updated 15 days ago.


    Collection: 4, Score: 1392, Trend score: 0, Read count: 1391, Articles count: 9, Created: 2015-05-21 01:37:12 UTC. Updated: 2021-02-09 21:39:28 UTC.

    Notes

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    1

    Hydroxyethyl starches, such as Hespan, Voluven, Volulyte, Tetrahes and Hestar, have been shown in several large trials to increase the risk of acute kidney injury (AKI) and/or the need for renal replacement therapies among critically ill patients, particulalry those suffering sepsis.

    Evidence demonstrating harm among fit & healthy surgical patients is however lacking, notably Giles et al could find no increased risk of adverse event among surgical patients in their 2014 meta-analysis. Nonetheless, given the similar lack of demonstrable benefit of HES fluids for this group, avoidance of use in both the ICU and surgical population is prudent.

    Daniel Jolley  Daniel Jolley
    pearl
    1

    Hydroxylethyl starch fluids increase the risk of acute kidney injury in the critically ill, and offer little benefit to general surgical patients.

    Daniel Jolley  Daniel Jolley
     
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