• Hydroxylethyl starches: harm and acute liver injury


    Daniel Jolley.

    9 articles.

    Created May 21, 2015, last updated 15 days ago.

    Collection: 4, Score: 1392, Trend score: 0, Read count: 1391, Articles count: 9, Created: 2015-05-21 01:37:12 UTC. Updated: 2021-02-09 21:39:28 UTC.



    Hydroxyethyl starches, such as Hespan, Voluven, Volulyte, Tetrahes and Hestar, have been shown in several large trials to increase the risk of acute kidney injury (AKI) and/or the need for renal replacement therapies among critically ill patients, particulalry those suffering sepsis.

    Evidence demonstrating harm among fit & healthy surgical patients is however lacking, notably Giles et al could find no increased risk of adverse event among surgical patients in their 2014 meta-analysis. Nonetheless, given the similar lack of demonstrable benefit of HES fluids for this group, avoidance of use in both the ICU and surgical population is prudent.

    Daniel Jolley  Daniel Jolley

    Hydroxylethyl starch fluids increase the risk of acute kidney injury in the critically ill, and offer little benefit to general surgical patients.

    Daniel Jolley  Daniel Jolley
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