Article Notes
- Coloured drug labels with barcodes.
- Computerised drug crosscheck.
- Computerised allergy and drug expiration alerts.
- Re-organised anaesthesia workplace, focusing on the drug administration workflow.
- Prefilled syringes for: calcium chloride, ephredrine, fentanyl, lidocaine, magnesium sulphate, metaraminol, midazolam, neostigmine, and pancuronium.
- Automated computerised anaesthetic record.
- Webster (2001): The frequency and nature of drug administration error during anaesthesia
- Merry (2001): A new, safety-oriented, integrated drug administration and automated anesthesia record system
- Webster (2004): A prospective, randomised clinical evaluation of a new safety-orientated injectable drug administration system in comparison with conventional methods.
- Whether SGA placement is detrimental or beneficial, compared with basic airway support, and;
- Whether there is any difference if the arrest occurs at the scene or in the confines of an ambulance.
An interesting and thought-provoking study, even with its flaws.
The authors concluded that system changes surrounding anaesthetic drug delivery reduce medication error.
A ‘care bundle’ approach was taken to improve drug safety through system design and human factors considerations:
But the problems...
No randomisation, no blinding, observational study, completely voluntary use of the safety system and self-reporting of errors...
Were the improvements due to the intervention, or simply a greater interest and priority given to anaesthetic safety? (Would it matter?)
In only 15% of anaesthetics was the new system (voluntarily) used, and thus may represent anaesthetists more motivated to prioritise medication safety over convenience or convention.
Finally error is being used (not unreasonably) as a surrogate marker for patient harm. (Although the authors did try to sneak in... “a non-significant reduction (p=0.055) in the harm attributable to drug administration error” 🙄)
Final word of caution
Even this quite impressive system was not immune to error. There were 19 cases of violation of the video and/or audio crosscheck before drug administration. Automated safety systems are obviously no panacea.
Additionally, although there was an observed reduction in all drug errors, there was no reduction specifically in drug substitution error.
Nonetheless a refreshing and novel approach to anaesthetic drug safety, beyond the typical admonishment to just be safer.
More on the system used:
What is this?
This Korean study investigated 6,620 out-of-hospital cardiac arrests (OHCA) witnessed by emergency medical providers, covering a four year period of the Korean OHCA registry. They looked at outcome among those receiving advanced airway intervention, comparing arrest at scene to arrest in the ambulance.
Why is this interesting?
Past studies have suggested better OHCA outcomes when a supraglottic airway (SGA) is used rather than endotrachial intubation (ETI). We also know that repeated advanced airway attempts are detrimental, and that airway intervention can interrupt CPR.
What was not known is:
And they found:
There was no benefit from advanced airway intervention (SGA or ETI) for EMS witnessed out-of-hospital arrest – and in fact there was an associated worse neurological outcome for in-ambulance OHCA when the airway was instrumented compared to any other group.
Don’t be hasty...
Although the authors reasonably describe the ways in which providing advanced airway interventions in the confines of an ambulance may impede other resuscitation, thus worsening outcomes, it may also be that a patient who still arrests despite receiving EMS care in the back of an ambulance is by definition at risk of worse outcomes despite medical care.
Nevertheless, at worst this retrospective observational study suggests there is no benefit of advanced airways in OHCA.
Bonus...
The authors also provide an interesting overview of the Korean emergency medical system, servicing 50 million people in urban and rural areas. This is an enlightening insight into how one country has structured its EMS service.