Perioperative benzodiazepine use is associated with decreased risk of intraoperative awareness but no increase in postoperative delirium unless compared with dexmedetomidine.
Transdermal & buccal buprenorphine is associated with a small reduction in pain scores in chronic non-cancer pain.
Interesting rat study suggesting a hypothesis for the neuroprotective effects of hypothermia on cerebrocortical damage arising from hypoxia and hypoglycaemia.
Better glial integrity may be a neuroprotection mechanism of early hypothermia.
Note this is a systemic review of a small number of RCTs published very early in the COVID-19 pandemic, and notably only one of the four RCTs included coronarvirus, Loeb (2009), the others mainly focusing on influenza [MacIntyre (2011), MacIntyre (2013), Radonovich (2019)]. Obviously none of the studies specifically looked at SARS-CoV-2.
Subsequent N95/P2 mask studies since this have shown significant benefit of high-quality masks in reducing COVID-19 transmission.
For paediatric anaesthesia premedication comparing midazolam 0.5 mg/kg to clonidine 4 µg/kg, there is no clinical or statistical difference in negative behaviour changes in 2 to 8 year olds at 1 week. Midazolam did however show significantly lower pre-induction anxiety.
Meta-analysis pooled data continues to suggest that processed-EEG guided general anaesthesia is associated with a slightly lower incidence of postoperative delirium compared to usual care or deeper-guided GA.
After Emergency Medical Services witnessed out-of-hospital cardiac arrest, pooled survival is approximately twice as high in Europe (26%) & Australasia (31%), than in North America (14%).
Corticosteroid treatment is associated with a reduction in all-cause mortality in severe COVID.
Physical activity is associated with lower incidence of COVID-hospitalisation in a non-linear dose-dependent fashion.