Although improving, 'harms reporting' in analgesic clinical trials is generally poor. On average the 101 studied analgesic trials met only 60% of harms reporting recommendations.
Sedation with TCI remifentanil targeting effect site concentration of 3 ng/mL resulted in detectable aspiration in almost 50% of the study participants after 1 hour.
Monitoring depth of anaesthesia in those over 60 yo decreases the incidence of post-operative delirium, though not post-operative cognitive decline.
While single-injection supraclavicular nerve block is faster to perform, triple-injection has faster onset and greater block success at 20 minutes.
Available evidence does not support the claim that nitrous oxide affects mortality or cardiovascular morbidity.
Interesting to note that not only did the pudendal nerve block group experience better analgesia than the caudal block group, they were also exposed to a much smaller absolute dose of bupivacaine (0.75 mg/kg vs 2.5 mg/kg). This is important not only because of the safety implications, but also because allows extra LA for top-up if the block is inadequate or fails.
Pudendal nerve block provides better analgesia in the first 24 hours for children following hypospadias repair than does caudal block.
Non-invasive haemoglobin monitoring devices show clinically-acceptable, though imperfect, accuracy when compared with laboratory Hb measurement.
Adductor canal block analgesia is comparable to femoral nerve block while improving early (6-8 h) quadriceps strength after total knee arthroplasty.
A single 60 mg/kg IV dose of magnesium sulphate does not impede rocuronium reversal by sugammadex.