Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Randomized Controlled Trial Comparative Study Clinical TrialRandomised control trial of tongue acupuncture versus sham acupuncture in improving functional outcome in cerebral palsy.
Traditional Chinese medicine (TCM) has been used historically in the treatment of cerebral palsy (CP). We investigated the efficacy of acupuncture in improving the motor function of children with CP. ⋯ An improvement in motor function of CP subjects is seen following a short course of acupuncture.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Randomized Controlled Trial Multicenter Study Clinical TrialMulticentre, randomised, double blind, placebo controlled, phase III study of weekly, low dose, subcutaneous interferon beta-1a in secondary progressive multiple sclerosis.
Interferon (IFN) beta has repeatedly shown benefit in multiple sclerosis (MS) in reducing the rate of relapse, the disease activity as shown with magnetic resonance imaging and, to some degree, the progression of disability; however, it is unknown how much the therapeutic response depends on the dose, the subgroup involved, and the disease stage. This multicentre, double blind, placebo controlled study explored the dose-response curve by examining the clinical benefit of low dose IFN beta-1a (Rebif), 22 micro g subcutaneously once weekly, in patients with secondary progressive MS. ⋯ This patient population was less clinically active than SPMS populations studied in other trials. Treatment with low dose, IFN beta-1a (Rebif) once weekly did not show any benefit in this study for either disability or relapse outcomes, including a subgroup with preceding relapses. These results add a point at one extreme of the dose-response spectrum of IFN beta therapy in MS, indicating that relapses in this phase may need treatment with higher doses than in the initial phases.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Randomized Controlled Trial Clinical TrialClozapine in drug induced psychosis in Parkinson's disease: a randomised, placebo controlled study with open follow up.
To compare the efficacy and safety of clozapine in drug induced psychosis in Parkinson's disease (PD). ⋯ Clozapine at a mean dose lower than 50 mg/day improves drug induced psychosis in PD without significant worsening of motor function, and the effect wears off once the treatment stops.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Randomized Controlled Trial Clinical TrialUse of short term video EEG in the diagnosis of attack disorders.
Distinguishing epileptic from psychogenic non-epileptic seizures (PNES) often requires video electroencephalography (EEG) recording. Inpatient recording is a limited resource; some evidence suggests that short term video EEG (SVEEG) is useful, but its role in practice has yet to be evaluated. ⋯ SVEEG is a robust and useful diagnostic technique, which complements existing resources.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2004
Letter Randomized Controlled Trial Clinical TrialThe effect of interferon beta-1a on spasticity in primary progressive multiple sclerosis.