Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Biography Historical ArticleLewis Carroll's Humpty Dumpty: an early report of prosopagnosia?
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J. Neurol. Neurosurg. Psychiatr. · Jun 2004
Comparative StudyWhite matter hyperintensities are significantly associated with cortical atrophy in Alzheimer's disease.
Methodological variability in the assessment of white matter hyperintensities (WMH) in dementia may explain inconsistent reports of its prevalence and impact on cognition. We used a method of brain MRI segmentation for quantifying both tissue and WMH volumes in Alzheimer's disease (AD) and examined the association between WMH and structural and cognitive variables. ⋯ Objective measurements of tissue volumes in AD demonstrated that WMH are significantly related to cortical atrophy and neuropsychological impairment.
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J. Neurol. Neurosurg. Psychiatr. · Jun 2004
Comparative StudyMotor overflow in Huntington's disease.
We investigated both motor overflow and ability to control voluntary movement in patients with Huntington's disease (HD). We hypothesised that, compared with controls, overflow would be significantly greater in HD participants and that they would exhibit poorer control of voluntary movement. ⋯ In addition, the degree of overflow in HD participants positively correlated with overall UHDRS motor symptom severity. The presence of exacerbated motor overflow in HD, and its correlation with symptom severity, is an important finding worthy of further investigation.