Journal of neurology, neurosurgery, and psychiatry
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While obesity in midlife is a risk factor for dementia, several studies suggested that obesity also protected against dementia, hence so-called obesity paradox. The current study aims to address the relationship between apolipoprotein E (APOE) genotype and obesity in dementia. ⋯ Obesity may accelerate cognitive decline in middle to early elderly cognitive normal individuals without APOE4 likely by provoking vascular impairments. On the other hand, obesity may ease cognitive impairment in both individuals with dementia and individuals at the predementia stage, especially those with APOE4, through protecting against Alzheimer's pathologies. These results support that APOE genotype modifies the obesity paradox in dementia.
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J. Neurol. Neurosurg. Psychiatr. · Jan 2024
Non-invasive fluid biomarkers in the diagnosis of mild traumatic brain injury (mTBI): a systematic review.
Despite approximately 55.9 million annual mild traumatic brain injuries (mTBIs) worldwide, the accurate diagnosis of mTBI continues to challenge clinicians due to symptom ambiguity, reliance on subjective report and presentation variability. Non-invasive fluid biomarkers of mTBI offer a biological measure to diagnose and monitor mTBI without the need for blood draws or neuroimaging. The objective of this study is to systematically review the utility of such biomarkers to diagnose mTBI and predict disease progression. ⋯ CRD42022329293.
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J. Neurol. Neurosurg. Psychiatr. · Jan 2024
Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions.
The cingulate gyrus (CG), a brain structure above the corpus callosum, is recognised as part of the limbic system and plays numerous vital roles. However, its full functional capacity is yet to be understood. In recent years, emerging evidence from imaging modalities, supported by electrical cortical stimulation (ECS) findings, has improved our understanding. To our knowledge, there is a limited number of systematic reviews of the cingulate function studied by ECS. We aim to parcellate the CG by reviewing ECS studies. ⋯ Our results provide a segmental mapping of the functional properties of CG, helping to improve precision in the surgical planning of epilepsy.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2024
Resective epilepsy surgery and its impact on depression in adults: a systematic review, meta-analysis, and implications for future research.
How epilepsy surgery influences the bidirectional relationship of epilepsy and depression remains poorly defined. ⋯ CRD42022355386.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2024
Observational StudyPragmatic computerised perfusion diagnostics for non-convulsive status epilepticus: a prospective observational study.
Non-convulsive status epilepticus (NCSE) is a time-dependent neurological disorder often misdiagnosed in the emergency setting. Electroencephalography (EEG) is often not available on a 24/7 basis, and Salzburg criteria may at times miss the diagnosis. Here, we tested the accuracy of hyperperfusion on CT perfusion imaging (CTP) in the identification of NCSE against Salzburg criteria, to define its potential role in a pragmatic diagnostic workflow. ⋯ CTP hyperperfusion may be implemented in the emergency fast-track to rule out NCSE, given very high NPV. Further validation studies are needed to evaluate CTP application in real-world setting for NCSE codes.