International journal of geriatric psychiatry
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Int J Geriatr Psychiatry · Jan 2021
Review Meta AnalysisThe risk factors for postoperative delirium in adult patients after hip fracture surgery: a systematic review and meta-analysis.
Postoperative delirium (POD) is the most common complication in patients after hip fracture surgery, and the incidence of POD is associated with mortality and disability in patients following hip fracture surgery. Therefore, this study aimed to identify the individual as well as anesthetic and operative risk factors associated with the POD in adult patients after hip fracture surgery. ⋯ Patients possessed above risk factors might be high-risk patients. Clinician should maintain keen vigilance at those patients.
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Int J Geriatr Psychiatry · Jul 2021
Affective symptoms and regional cerebral tau burden in early-stage Alzheimer's disease.
Neuropsychiatric symptoms (NPS) are often present in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. NPS are associated with structural and functional changes in the brain such as atrophy, regional hypometabolism, and hypoperfusion, considered proxies of neurodegeneration. Our objective was to evaluate the association between NPS and regional cerebral tau burden, a more direct representation of neurodegeneration, in cognitively normal (CN), MCI, and AD dementia individuals. ⋯ Increased tau burden in the entorhinal and precuneus cortices was modestly associated with greater NPS in MCI and AD dementia. Further evaluation of NPS and their effect on early-stage AD could aid in finding new interventions and slowing disease progression.
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Int J Geriatr Psychiatry · Oct 2020
Prospective longitudinal evaluation of cytokines in mild cognitive impairment due to AD and Lewy body disease.
We conducted a prospective longitudinal study of plasma cytokines during the Mild Cognitive Impairment (MCI) stage of Lewy body disease and Alzheimer's disease, hypothesizing that cytokine levels would decrease over time and that this would be correlated with decline in cognition. ⋯ Peripheral inflammation decreased in both disease groups during MCI suggesting this may be a therapeutic window for future anti-inflammatory agents.
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Int J Geriatr Psychiatry · Apr 2021
A novel hybrid scale for the assessment of cognitive and executive function: The Free-Cog.
Scales measuring cognitive and executive functions are integral to the assessment and management of patients with suspected cognitive impairment. Some of the most commonly used cognitive tests are now subject to copyright restrictions. Furthermore, no existing scale assesses both executive and cognitive abilities. ⋯ Free-Cog is a non-proprietary, empirically derived, concise assessment. Uniquely, it combines cognitive and executive function questions in the one instrument. It could be used to inform the assessment of people presenting with cognitive impairment and is available to anyone interested in trialling it.
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Int J Geriatr Psychiatry · Nov 2020
Dual and triple tasks performance in institutionalized prefrail and frail older adults.
The aim of this pilot study was to investigate differences on dual- and triple-task performance in institutionalized prefrail and frail older adults. Performance on these tasks is relevant since many activities of daily living involve simultaneous motor and cognitive tasks. ⋯ Although future studies need to confirm our observations in larger samples, this pilot study suggests that developing new tools based on triple tasking could be useful for the comprehensive assessment of frailty.